Testolactone

Chemical Name 2-[(2,6-Dichloro-3-methvlphenyl)amino] benzoic acid ethoxymethyl ester Common Name Etoclofene Structural Formula  

6-Dichloro-m-tolylanthranilic acid Chloromethyl ethyl ether 

10 g sodium salt of N-2,6-dichloro-m-tolylanthranilic acid, 3 ml chloromethyl ethyl ether and 80 ml dry acetone were refluxed for 12 hours on waterbath under stirring. The solid was filtered off, and the solution evaporated to dryness. The residue was dissolved in chloroform, washed with sodium carbonate solution, then with water until neutral. After drying on sodium sulfate, the solution was evaporated to dryness. The obtained product was recrystallized from 95% ethanol. Melting point 73°C to 74°C, 

Manghisi, E. U.S. Patent 3,642,864 February 15, 1972 assigned to Istituto Luso Farmaco D ltalia S.R.L. (Italy) 

Therapeutic Function Cancer chemotherapy Chemical Name D-homo-17-a-oxaandrosta-1,4-diene-3,17-dione Common Name 1-dehydrotestololactone Structural Formula  

Bacterium Cylindrocarpon radicola Corn steep liquor Brown sugar 

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USP (Megace) testolactone USP [968-93 ] C19H24O3 300.40 (61) or endrome-trium breast cancer hyper-calcemia common side effects of steroids fluid retention ... 

Terolidine 2, 56 Tesicam T79 Tesimide 296 Testolactone 160 Testosterone cypionate 1, 172 Testosterone decanoate T, 172 Testosterone propionate 1, 172 Tetrabenazine 350 Tetracaine 1, 110 Tetracycline 1, 212 Tetrahydrocannabinol, A-1, 1, 394... 

C21H30O2 57-.S3-0) see Alfaxalone Cortisone Desoxycortone acetate Hydrocortisone Testolactone proglumide... 

Aromatase inhibitors (including anastrozole, letrozole, aminoglutethimide, exemestane, formestane, testolactone), selective estrogen receptor modulators—SERMs (including raloxifene, tamoxifen, toremifene), clomiphene, cyclofenil, fulvestrant Diuretics, amiloride, bumetanide, canrenone, chlorthalidone, etacrynic acid, furosemide, indapamide, metolazone, spironolactone, thiazides, triamterene... 

Taclamine, 224 Talampicillin, 438 Talopram, 357 Tamoxifen, 127 Tandamine, 347, 460 Tazolol, 110, 268 Teclozan, 28 Temazepam, 402 Terodiline, 56 Tesicam, 379 Tesimide, 296 Testolactone, 160 Tetrahydropyrimidine synthesis, 303 Tetrahydroquinoline synthesis, 371 Tetrazole synthesis, 301,... 

The combination of spironolactone (2 mg/kg/day) and testolactone (20 to 40 mg/kg/day) for 6 months or more may be effective for short-term treatment of familial male precocious puberty. 

Testolactone is a synthetic drug related to testosterone. It is used for palliative treatment of advanced breast cancer in postmenopausal women and in women who have had their ovaries removed. The principal action of testolactone is reported to be inhibition of steroid aromatase activity and the reduction in estrone synthesis. The most common adverse effects are nausea, vomiting, and anorexia. An advantage is that it does not cause women to develop male characteristics such as a deep voice or facial hair. 

Stanozolol (Winstrol), Testolactone (Teslac), Testosterone and its esters... 

The API testolactone will undergo ring opening of the lactone to A -testolic acid in strongly alkaline solution (Fig. 3) (8). 

The prototypical steroidal inhibitor of aromatase (the enzyme required for estrogen synthesis) is testolactone. It is a weak inhibitor of the enzyme, and large quantities need to be administered to achieve clinical effect. 

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