Terramycin Oxytetracycline

Tetracycline and several related antibiotics (aureomycin = chlorotetracycline, terramycin — oxytetracycline dihydrate) are also obtained from various species of Streptomyces, but are of very different structure, being based on the fused polycyclic arene naphthacene. The presence of five hydroxy substituents (six for terramycin) and an NMe2 group, and possibilities for various conformations and tautomers, complicate the study of their... 

Terramycin oxytetracycline. tertatolol [ban, inn] is a P-adrenoceptor antagonist with (5-HT,a) 5-hydroxytryptamine receptor antagonist properties. It was formerly used for its antihypertensive and vasodilator properties. 

Streptomycin preparations generally contain 1.5% terramycin to prevent the development of resistance to streptomycin. Terramycin (oxytetracycline) belongs to the tetracyclic antibiotics, isolated by Finlay et al. (1950) from Streptomyces rimosus culture (2). It is an antibiotic with contact and systemic fungicidal action, and has been recommended alone for protection against Puccinia triticina and Xanthomonas pruni (Muller, 1969, Keil and Civerolo, 1979). 

Important tetracyclines include chlortetracycline (Aureomycin) and oxytetracycline (Terramycin). Tetracyclines are broad-spectrum antibiotics, which means that they... 

Tetracycline (SUBAMYCIN) Oxytetracycline (TERRAMYCIN) Chlortetracycline (AUREOMYCIN) Demeclocycline (LEDERMYCIN) Doxycycline (BIODOXI) Minocycline (CANOMYCIN)... 

Exercise 30-13 a. The structure of Terramycin (an oxytetracycline antibiotic) is shown below. This substance is a mold metabolite and shows extensive incorporation of 14C when GH3—uC02H is introduced into the culture medium. Indicate positions expected for introduction of the 14C-label in Terramycin using CH3—14C02H. 

Oral 50, 100 mg tablets and capsules 50 mg/5 mL suspension Parenteral 100 mg powder to reconstitute for injection Oxytetracycline (generic, Terramycin)... 

Oxytetracycline ("Terramycin) Inhibits root and shoot growth and also stimulates growth in Reuiexiin... 

Oxytetracycline (Terramycin) Short-acting Protein-Binding 20%e—40% Half-Life 6-10 hours PO IV 250-500 mg 250-500 mg Every 6 hours Infusion every 12 hours... 

In structural studies on oxytetracycline (Terramycin) and chlorotetracycline (Aureomycin) a Pfizer group found that tosyl chloride in cold pyridine converts the antibiotics into nitrile derivatives through dehydration of the primary carbox-amido group. They then found that simpler amides are dehydrated to nitriles in good yield by adding 1 equivalent of tosyl chloride slowly to a mixture of the amide with 2.25 equivalents of pyridine at a rate such as to maintain a temperature of about 70°. The mechanism proposed involves O-tosylation. 

One year later, the American pharmaceutical company Pfizer discovered a related structure - christened oxytetracycline (Terramycin) - from Streptomyces rimosus. Interestingly, this was found in a soil sample located near their factory in Terre Haute, Indiana. The parent structure - tetracycline - was then obtained by chemical removal of the chlorine atom (an element only rarely found in terrestrial organisms but common in natural products from marine organisms) from chlortetracycline. This third antibacterial agent was subequently found naturally as a constituent of both Streptomyces aureofaciens and Streptomyces viridifaciens. The structures of chlortetracycline were established by R.B. Woodward in 1952 and that of oxytetracycline by Pfizer scientists (in collaboration with RBW) in 1952. 

HYDROCHLORIDE/POLYMYXIN B SULFATE (Terak with Polymyxin B sulfate ophthalmic ointment 10,000 units/g Polymyxin B sulfate and 5 mgfg oxytetracycline hydrochloride, Terramycin with Polymyxin B sulfate ophthalmic ointment 10,000 units/g Polymyxin B sulfate and 5 mg/g oxytetracycline hydrochloride)... 

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