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Terpenoid indole alkaloids vincristine

After their discovery, the Vinca alkaloids became the first natural anticancer agents to be clinically used, and they are still an indispensable part of most curative regimens used in cancer chemotherapy nowadays. On the other hand, the plant producing these alkaloids, C. roseus, has become one of the most extensively studied medicinal plants. The levels of vincristine and vinblastine in the plant revealed to be extremely low and, for pharmaceutical production, approximately half a ton of dry leaves is needed to obtain 1 g of vinblastine [4]. This feet stimulated intense investigation in alternative methods for the production of vinblastine and vincristine, namely chemical synthesis and plant cell cultures. However, chemical synthesis showed not to be viable due to the high number of transformations involved, and the anticancer alkaloids were never detected in cell cultures, which express alkaloid metabolism very poorly [5, 6]. The biosynthetic pathway of terpenoid indole alkaloids in C. roseus has also been intensively studied with the objective of developing a manipulation strategy to improve the levels of the anticancer alkaloids in the leaves of the plant [5, 7-10]. [Pg.815]

After the discovery of the anticancer properties of vinblastine and vincristine, the elucidation of their structure, Fig. (1), was a natural step achieved in the early 60s [26, 27], and it was shown that they were dimeric terpenoid indole alkaloids - as already stated above. Simultaneously, further studies of the plant C. roseus revealed that this plant is an amazing chemical factory, producing more than 100 different terpenoid indole alkaloids, including two other with important pharmacological activity ajmalicine, used as an antihypertensive, and serpentine, used as sedative [6, 28]. [Pg.819]

L-Tryptophan is an indole ring containing aromatic amino acid derived via the shikimate pathway. The tryptophan-derived alkaloids are found in eight families, of which, Apocynaceae, Loganiaceae, Rubiaceae, and Nyssaceae are the best sources. The alkaloids under discussion are the Catharanthus alkaloids, namely, ajmalicine, tabersonine, catharanthine, vindoline, vinblastine, vincristine and vincamine as well as terpenoid alkaloids derived from other families, namely, yohimbine, reserpine, strychnine, brucine, and ellipticine. The above-mentioned alkaloids are pharmacologically very important and hence extremely valuable. This chapter describes various aspects of the tryptophan-derived alkaloids like occurrence, biological activity, phytochemistry, and commercial and biotechnological aspects. [Pg.576]


See other pages where Terpenoid indole alkaloids vincristine is mentioned: [Pg.479]    [Pg.479]    [Pg.356]    [Pg.112]    [Pg.25]    [Pg.323]    [Pg.120]    [Pg.813]    [Pg.816]    [Pg.323]    [Pg.222]    [Pg.88]    [Pg.233]    [Pg.2961]    [Pg.4327]    [Pg.187]    [Pg.255]    [Pg.455]    [Pg.494]    [Pg.243]    [Pg.113]    [Pg.826]    [Pg.88]    [Pg.31]   
See also in sourсe #XX -- [ Pg.323 ]

See also in sourсe #XX -- [ Pg.323 ]




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Alkaloids indole, terpenoid

Alkaloids terpenoid

Terpenoid

Terpenoidal alkaloid

Terpenoides

Terpenoids

Vincristin

Vincristine

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