Terminal region

Fig. 5. Schematic diagram of the presumed arrangement of the amino acid sequence for the 5-opioid receptor, showing seven putative transmembrane segments three intracellular loops, A three extracellular loops, B the extracellular N-terrninus and the intracellular C-terrninus, where (0) represents amino acid residues common to ] -, 5-, and K-receptors ( ), amino acid residues common to all three opioid receptors and other neuropeptide receptors and (O), other amino acids. Branches on the N-terruinal region indicate possible glycosylation sites, whereas P symbols in the C-terminal region indicate...

A terminal region where the residual centerline velocity reduces rapidly within a short distance. For air jets, the residual velocity will reduce to less than 0.3 m/s, (1.0 ft/s) usually considered still air. 

Figure 4.5 The polypeptide chain of the enzyme pyruvate kinase folds into several domains, one of which is an a/p barrel (red). One of the loop regions in this barrel domain is extended and comprises about 100 amino acid residues that fold into a separate domain (blue) built up from antiparallel P strands. The C-terminal region of about 140 residues forms a third domain (green), which is an open twisted a/p structure.

Figure 6.12 (a) Schematic diagram of one subunit of GroEL. The polypeptide chain is folded info three domains. The equatorial domain (green) is the largest domain, comprising 10 a helices, and is built up from both the N-tetminal and the C-terminal regions. 

The helices at the N-terminal regions of the two polypeptide chains are intertwined and make extensive contacts in the central part of the molecule to form a stable core. This core supports two "heads", each comprising the last three helices from one polypeptide chain. Alpha helix 3 in the middle of the subunit chain is quite long and forms the main link between the core and the head. 

Figure 8.19 The a helices of the N-terminal region of the trp repressor are involved in subunit interactions and form a stable core in the middle of the dimer. Alpha helices 4-6, which include the helix-turn-helix motif, form two "head" regions at the two ends of the molecule. Alpha helix 3 connects the core to the head in both subunits. (Adapted from R.W. Schevitz et al., Nature 317 782-786, 1985.)...

TBP mutants lacking the N-terminal region are fully functional in promoter binding and stimulation of basal transcription and therefore these two functions must be provided by the C-terminal domain. Furthermore, the C-terminal domain of yeast TBP contains all the functions essential for normal yeast cell growth and for responses to specific transcriptional activators with a net negative charge. This C-terminal domain contains two homologous... 

Figure 11.13 Schematic diagram of the three-dimensional structure of subtilisin viewed down the central parallel p sheet. The N-terminal region that contains the a/p stmcture is blue.

Both the a and the y subunits of G proteins are anchored to the membrane by lipids covalently bound to the N-terminal region of the Ga chain... 

Adenosine Receptors. Figure 3 An alignment of the primary sequences of the four human AR subtypes. Regions of conservation are highlighted. indicates the most conserved (X.50) residue in each TM region. Bold residues correspond to those indicated in Table 1. The A2A receptor is truncated in the carboxy-terminal region. 

Both psychostimulants D-amphetamine and cocaine elevate extracellular dopamine concentrations in the terminal region of midbrain dopamine neurons,... 

Expressed Sequence Tag. A short DNA sequence usually representing the most terminal regions of a cDNA clone. 

Histone tails are the N-terminal regions of histones which reach outside the nucleosomes. They are not essential for the formation in of nucleosomes but are required for the formation of higher-order chromatin structures. The histone tails are also known to be heavily posttranslationally modified by acetylation, phosphorylation, methylation, etc. and are important for the regulation of gene activity. 

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