Teratogenic aluminum

Domingo JL, Gomez M, Bosque MA, et al. 1989. Lack of teratogenicity of aluminum hydroxide in mice. Life Sci 45 243-247. 

Gonda Z, Lehotzky K. 1997. Behavioural teratogenic effect of aluminum exposure in rat offspring. Neurotoxicology 18 1092. 

Patemain JL, Domingo JL, Llobet JM, et al. 1988. Embryotoxic and teratogenic effects of aluminum nitrate in rats upon oral administration. Teratology 38 253-257. 

ACGIH TLV TWA 2 mg(Al)/m3 DOT CLASSIFICATION 8 Label Corrosive SAFETY PROFILE Moderately toxic by ingestion. Experimental teratogenic and reproductive effects. Mutation data reported. The dust is an irritant by ingestion, inhalation, and skin contact. Highly exothermic polymerization reactions with alkenes. Incompatible with nitrobenzenes or nitrobenzene + phenol. Highly exothermic reaction with water or steam produces toxic ftimes of HCl. See also ALUMINUM COMPOUNDS, CHLORIDES, and HYDROCHLORIC ACID. 

SAFETY PROFILE Confirmed carcinogen with carcinogenic data reported. Poison by intraperitoneal route. Moderately toxic by ingestion, inhalation, and skin contact. Experimental teratogenic and reproductive effects. A skin irritant. Human mutation data reported. Animal experiments suggest somewhat lower toxicity than for related epoxy compounds. Readily absorbed through the skin. Causes nervous excitation followed by depression. Explodes when heated or in the presence of strong acids, bases, metals (e.g., copper, zinc), and metal salts (e.g., aluminum chloride, iron(III) chloride, tin(TV) chloride). When heated to... 

Toxicology ACGIH TLV/TWA 10 ppm LD50 (oral, rat) 156 mg/kg, (subcut., mouse) 1150 mg/kg, (skin, rabbit) 277 mg/kg poison by ing., skin contact, IP mod. toxic by subcut. severe human skin irritant can cause dermatitis corrosive human mutagenic data experimental teratogen, reproductive effects TSCA listed Precaution Flamm. liq. dangerous fire hazard exposed to heat, flame, or oxidizers corrosive to copper and copper alloys, aluminum, zinc, and... 

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