Temporal Factors System response time

A potential problem when measuring drug activity relates to the temporal ability of systems to come to equilibrium, or at least to a steady state. Specifically, if there are temporal factors that interfere with the ability of the system to return cellular response, or if real-time observation of response is not possible at the time of exposure to drugs, especially... 

The main characteristics which determine the performance of a wavefront corrector are the number of actuators, actuator stroke and the temporal response. The number of actuators will determine the maximum Strehl ratio which can be obtained with the AO system. The price of a deformable mirror is directly related to the number of actuators. The actuator stroke should be enough to compensate wavefront errors when the seeing is moderately poor. This can be derived from the Noll formula with ao = 1.03. For example, on a 10m telescope with ro = 0.05m at 0.5 m, the rms wavefront error is 6.7 /xm. The deformable mirror stroke should be a factor of at least three times this. It should also include some margin for correction of errors introduced by the telescope itself. The required stroke is too large for most types of deformable mirror, and it is common practice to off-load the tip-tilt component of the wave-front error to a separate tip-tilt mirror. The Noll coefficient a2 = 0.134 and... 

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