Technetium complexes diagnostic imaging techniques, bone

Complexes of the diphosphonic acid (12.125b) with y-ray-emitting isotopes of technetium are useful for medical diagnostic work since they concentrate in the bone. The use of technetium diphosphonate complexes for bone imaging (MRl below) has revolutionised bone-scanning techniques. Technetium pyrophosphate complexes are less satisfactory since the P-O-P linkages are liable to hydrolysis by body enzymes [11,12]. 

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