Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Tax ane

Three classes of plant-derived drugs, the vinca alkaloids (vincristine, vinblastine, and vinorelbine), the epipodo-phyllotoxins (etoposide and teniposide and the tax-anes (paclitaxel and taxotere), are used in cancer chemotherapy. These classes differ in their structures and mechanisms of action but share the multidrug resistance mechanism, since they are all substrates for the multidrug transporter P-glycoprotein. [Pg.648]

Kingston DGl, Newman DJ. Taxoids cancer-fighting compounds from nature. Curr. Opin. Drug Disc. Dev. 2007 10 130-144. Gradishar WJ. Albumin-bound paclitaxel a next-generation tax-ane. Exp. Opin. Pharmacother. 2006 7 1041-1053. [Pg.1151]

Rearrangement of a tetrasubstituted epoxide is a key step (equation 43) in a recent approach to the tax-ane ring system. ... [Pg.744]

Longo R, D Andrea M, Sarmiento R, Gasparini G (2010) Pharmacogenetics in breast cancer focus on hormone therapy, tax-anes, trastuzumab and bevacizumab. Expert Opin Investig Drugs 19(Suppl 1) S41-S50... [Pg.114]

Carboplatin has been used in the treatment of platinum-refractory ovarian cancer. Kavanagh and coUeagnes treated 33 platinum-refractory ovarian cancer patients with disease progression after tax-ane salvage therapy with carboplatin 300 mg/m every 28 days. These investigators noted a 21% partial response rate, a 39% stabilization rate, and a median response duration greater than 7 months. However, aU responding patients had a platinum-free interval of at least 12 months. [Pg.2474]

The author s work on the HPLC analysis of taxines was a follow-up of previous research work on the HPLC of taxanes. ° Unknown peaks present in the analysis of plant and cell culture extracts were suspected to be taxines. In previous works, several other researchers have reported the detection of impurity peaks in the extracts of Taxus X media (Hicksii) needles during the determination of tax-anes. These uncharacterized impurities showed a UV maximum at 280 nm, with a A280M228 ratio of approximately... [Pg.2283]

Using absorbance ratio with these two or similar wavelengths, the researchers managed to overcome quantitation problems. " Taxines and taxinines were also reported to cause problems in the HPLC analysis of tax-anes, coeluting with the peak of paclitaxel. [Pg.2283]

Ixabepilone is a semisynthetic derivative of epothilone B. It has been approved by the US FDA, for use as monotherapy or in combination with capecitabine for the treatment of locally advanced or metastatic breast cancer that is resistant or refractory to standard chemotherapy options (anthracyclines, tax-anes, capecitabine) [l J. It also has activity in prostate, renal, and pancreatic cancers and in non-small cell lung cancer. [Pg.948]

Baker SD. Drug interactions with the tax-anes. Pharmacotherapy 1997 17(5 Pt 2) 126S-132S. [Pg.955]

Markman M. Management of toxicities associated with the administration of tax-anes. Expert Opin Drug Saf 2003 2(2) 141-6. [Pg.959]


See other pages where Tax ane is mentioned: [Pg.712]    [Pg.712]    [Pg.473]    [Pg.242]    [Pg.242]    [Pg.1468]    [Pg.242]    [Pg.332]    [Pg.948]    [Pg.960]    [Pg.320]    [Pg.712]    [Pg.712]    [Pg.473]    [Pg.242]    [Pg.242]    [Pg.1468]    [Pg.242]    [Pg.332]    [Pg.948]    [Pg.960]    [Pg.320]   


SEARCH



ANES

© 2024 chempedia.info