Taurochenodeoxycholate

Abbreviations used for bile acids in Tables 3.1-3.6 DOC (deoxycholate), LC (lithocholate), CDOC (chenodeoxycholate), C (cholate), GDOC (glycodeoxycholate), TDOC (taurodeoxy-cholate), GCDOC (glycochenodeoxycholate), TCDOC (taurochenodeoxycholate), GC (gly-cocholate), TC (taurocholate). 

TDCA taurodeoxycholic acid, TCDCA taurochenodeoxycholic acid,... 

Sodium taurocholate Sodium taurochenodeoxycholate A Sodium taurodeoxycholate... 

Vibrio anguillarum glu, gin, gly, his, ile, leu, ser, fin, L-fucose, D-glucose, D-mannose, D-xylose, taurocholic acid, taurochenodeoxycholic acid 55... 

Secondary ion mass spectrometry Tuberculosis Taurocholic acid Taurochenodeoxycholic acid... 

The possibility that the biosynthesis of bile acids is regulated by a negative feedback mechanism was supported by early experiments by Thompson and Vars [206] and Eriksson [207], who showed that the rate of bile acid synthesis in rats increased about 10-fold when a bile fistula is made. Bergstrom and Danielsson demonstrated that duodenal infusion of taurochenodeoxycholic acid in bile fistula rats restored the increased synthesis to a normal rate [208]. Danielsson et al. [44] showed that the cholesterol 7a-hydroxylase activity increased in parallel with the bile acid synthesis after cannulation of the bile duct in rats. In a subsequent work by Mosbach et al., it was reported that the incorporation of isotope from labelled acetate, mevalonate and cholesterol but not from labelled 7a-hydroxycholesterol into bile acids was inhibited by duodenal infusion of taurocholate to bile fistula rats [209]. The incorporation of isotope from labelled acetate, mevalonate and cholesterol but not from labelled 7a-hydroxycholesterol was stimulated in perfused livers of cholestyramine-treated rabbits [210]. It was concluded that there are essentially no rate-limiting steps beyond 7a-hydroxycholesterol in the biosynthesis of bile acids from acetate. Since both cholesterol and bile acid biosynthesis was subjected to negative feedback inhibition by bile acids, it cannot be excluded that inhibition of cholesterol biosynthesis precedes inhibition of the bile acid biosynthesis, and that the latter inhibition is secondary to the former. 

The specificity of the inhibitory effect of bile acids on bile acid formation has been studied by Danielsson [110]. Taurocholic acid, taurochenodeoxycholic acid and taurodeoxycholic acid, fed at the 1% level in the diet for 3-7 days, were found to inhibit cholesterol 7a-hydroxylase activity. Feeding taurohyodeoxycholic acid and... 

Cyprinol sulfate was first found in bile of the eel. Conger myriaster, the principal bile salts of which are taurocholate and taurochenodeoxycholate [26], 5j8-Cyprinol sulfate was later found in the bile of some species of frogs as their principal bile salt [9,18,19,27], and was also detected in bile of some fishes as their minor bile salt [28,29], The structure of 5 8-cyprinol was determined as 5)8-choles-tane-3a,7a,12a,26,27-pentol by direct comparison with the synthetic sample prepared by Hoshita et al. before its isolation from natural sources [30], Partial synthesis of 5)8-cyprinol was also reported by Haslewood and Tammar [29],... 

Araya Z, Wikvall K. 6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes. Biochim Biophys Acta 1999 1438 47-54. 

Taurochenodeoxycholic acid (Chenodeoxycholoyltaurine) C26H45N06S 499.71 182-184 (Na salt) + 9° (C2H5OH, Na salt) 516-35-8... 

The results of Shefer et al. (152) support the conclusion by Lee et al. (146) that taurochenodeoxycholic acid has an effect on bile acid formation in rats with a biliary fistula not entirely related to the physiological regulation of bile acid formation, since the concentration of taurochenodeoxycholic acid needed to repress bile acid biosynthesis is less than half of that of taurocholic acid. 

Taurodeoxycholate and taurochenodeoxycholate were not separable nor were their glycine-conjugated counterparts. 

For bile salt mixtures, total concentration of bile salts is given. CTAB, cetyl trimethylam-monium bromide HDPC, hexadecyl pyridinium chloride lauryl taurate, sodium lauryl taurate TC-TDC, sodium taurocholate-sodium taurodeoxycholate ABS, sodium p-(H-octyl) benzene sulfonate SIC, a mixture of sodium taurocholate, sodium taurodeoxycholate, sodium taurochenodeoxycholate, sodium glycocholate, sodium glycodeoxycholate, and sodium glycochenodeoxycholate composed to resemble human small intestinal content during fat digestion and absorption (19). 

The biliary bile acids of germfree chicks have been shown by Haslewood (34) to be composed of approximately 80% taurochenodeoxycholic acid, 17% taurocholic acid, and 5% tauroallocholic acid. 

---