Taurine retinoic acid

In addition to bile acid conjugation, a variety of other compounds may also be excreted as taurine conjugates, including retinoic acid (Section 2.2.1.3) and a number of xenobiotics. 

Shirley, M.A. Bennani, Y.L. Boehm, M.F. Breau, A.P. Pathirana, C. Ulm, E.H. Oxidative and reductive metabolism of 9- s-retinoic acid in the rat. Identification of the 13,14-dihydro-9-cis-retinoic acid and its taurine conjugate. Drug Metab.Dispos., 1996, 24, 293-302... 

The findings of Fidge et al. (1968) were consistent with earlier observations (Zachman and Olson, 1965 Zachman et al., 1966) that retinoic acid, injected into the portal vein, was rapidly metabolized and excreted in the bile. The labeled compounds found in bile consisted of a mixture of polar metabolites, most of which were more polar than free retinoic acid. One of the metabolites of retinoic acid in bile has been identified as retinoyl -glucuronide (Dunagin et al., 1965 Zile et al., 1980, 1982a Swanson et al., 1981). Other polar metabolites account for most of the radioactivity in bile after administration of labeled retinoic acid to rats (Zile et al., 1980, 1982a) one of these has been identified as a taurine conjugate of a retinoic acid metabolite (Skare et al., 1982). 

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