Tau Beta

Kenneth L Walter, Ph.D. Process Manager—Technology, Aker Kvaerner, Inc. Senior Member, American Institute of Chemical Engineers, Sigma Xi, Tau Beta Pi (Storage and Process Vessels)... 

Keywords Glycogen synthase kinase 3 Alzheimer s disease Tau Beta amyloid... 

In a prospective study designed to investigate the pharmacodynamic effects of Uthium treatment on GSK-3 activity in patients with mild Alzheimer s disease, 71 patients received either lithium or a placebo for 10 weeks. Patients where assessed for cerebrospinal fluid (CSF) phospho-tau levels and cognitive function was assessed by Alzheimer s disease assessment scale (ADAS-Cog). No effect of lithium on CSF phosphorylated tau levels could be shown. However, a clinically significant effect on cognition was measured by ADAS-Cog [101]. It is feasible that a 10-week lithium treatment might not be sufficient to see an effect on phosphorylated tau or that GSK-3 inhibition will not be reflected in the CSF phospho-tau or total tau levels. CSF turnover is quite rapid (about 6 h) and a more predictive readout might be the tau/beta amyloid ratio that has been shown to be more sensitive [ 102]. 

Student Chapter of Tau Beta Pi, Engineering Honor Society... 

Paul joined the DuPont company in 1941 and retired as a senior research fellow in 1976. He was awarded 37 patents by the U.S. Patent Office and has pubHshed about 40 reports in scientific journals and a book on "Condensation Polymers". He is a member of the American Chemical Society, Phi Kappa Phi, Tau Beta Pi, Phi Lambda Upsilon and Sigma 3Q. He has served as National Coimcilor and Chairman of the Polymer Group of the American Chemical Society and chairman of the Delaware Section of the American Chemical Society. 

Tau Beta Pi Association http //www.tbp.org/pages/main.cfm (accessed Jnne 15, 2010). 

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