Targets molecular biology

Lynch DR, Guttmann RP (2001) NMDA receptor pharmacology perspectives from molecular biology Curr Drug Targets 2(3) 215-231... 

With further understanding how molecular rotors interact with their environment and with application-specific chemical modifications, a more widespread use of molecular rotors in biological and chemical studies can be expected. Ratiometric dyes and lifetime imaging will enable accurate viscosity measurements in cells where concentration gradients exist. The examination of polymerization dynamics benefits from the use of molecular rotors because of their real-time response rates. Presently, the reaction may force the reporters into specific areas of the polymer matrix, for example, into water pockets, but targeted molecular rotors that integrate with the matrix could prevent this behavior. With their relationship to free volume, the field of fluid dynamics can benefit from molecular rotors, because the applicability of viscosity models (DSE, Gierer-Wirtz, free volume, and WLF models) can be elucidated. Lastly, an important field of development is the surface-immobilization of molecular rotors, which promises new solid-state sensors for microviscosity [145]. 

The chemical functioning of a cell is the main objective of Molecular Biology (MB). The isolation, identification, and purification of biomacromolecules could be seen as the first step, in fulfilling this objective. From the catalytic point of view, enzymes are the center of attention. However, the most important biomolecule in the cell is the DNA, in which the genetic code of each enzyme is enclosed, thus representing ultimate target for MB. The biochemical and molecular processes of replication, transcription, and translation become part of the objective. 

Genomics gives us the tools to search for new therapeutic targets by providing new avenues of research. The application of advanced molecular biology techniques in conjunction with a complete understanding of genomic sequences will... 

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