Targets for Synthesis on Polymeric Supports

There are different strategies for making libraries wherein natural products skeletons have been constructed or immobilized on solid supports and subsequently derivatized  

Solid-phase target-oriented total synthesis of natural products  

Combinatorial derivatization for immobilized natural product skeletons  

Adaptation of new synthetic methods for the solid-phase synthesis of combinatorial libraries. 

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A key aspect of any synthesis strategy on a polymeric support is the linkage element, which acts as a tether to the polymeric support. Ideally, the linker should be stable to all reaction conditions used in a synthesis sequence and should be cleaved quantitatively under conditions that do not degrade the desired target molecule [6]. In this overview the different kinds of linkers and the synthetic transformations that can be used on polymeric supports will be presented. At the end, synthetic strategies for the synthesis of heterocycles and natural products will be mentioned. 

Peptide synthesis is usually carried out using solid phase chemistry on a beaded support which is derivitised with appropriate active groups that act as the synthesis points for peptide chains. Exposure of the peptide-support linkage to acidic conditions normally results in release of the peptide from the support, but use of an appropriate acid stable link between peptide and support as well as incorporation of cleavable cross-links within the beaded solid phase can be used to allow peptides to be synthesised in the usual way but remaining attached to the polymer backbone. In this way polymeric forms of the target peptide can be assembled in which the peptides are pendant from a polymer backbone. This approach has been reported to be useful for eliciting antibodies to peptide epitopes and in the induction of T cell responses. Such soluble polymeric supports have also been used in the preparation of immunoadsorbents which allow the preparation of antibodies from serum samples This approach does not, however, allow for the incorporation of large numbers of different peptide epitopes nor does it allow... 

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