Targeted poisons

Like the analysis of benzodiazepines in hair, the targeted analysis of the other drugs of interest by LC is accomplished predominantly with RPLC—triple quadrupole instruments [115,116,139—141]. 

Another drug of interest in DFCs is GFIB however, at the time of writing, only GC—MS and GC—MS/MS techniques have been applied to the analysis of GFIB in hair [143—146]. The challenge remains  

FIGURE 10.7 Extracted ion chromatograms of m/z 145.1097 suxamethonium as the internal standard m/z 183.0914 diaquat m/z 185.1070 paraquat, (a) and (b) are the product ions for paraquat precursor ion m/z 185.1062 and diaquat precursor ion m/z 183.0904 respectively. Analysis of postmortem blood. 

Glufosinate is structurally similar to glyphosate and used for similar herbicidal applications. The applications outlined here may also be used for this herbicide as well as other less commonly encountered analogs. 

LC has played a vital role in the field of forensic toxicology for several decades, either as an adjunct method to other chromatographic techniques or as a stand-alone STA detection method. While LC—DAD has a significant part to play in forensic toxicology, its weakness lies in relatively low sensitivity and specificity. 

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Like reactive evaporation, reactive sputtering is used in the deposition of refractory compounds by providing a small partial pressure of hydrocarbons, nitrogen, or oxygen. A problem is target poisoning caused by the reaction of the target with the reactive gas. 

In some reachve deposihon conhgurahons, the inert gas is injected around the sputtering target and the reactive gas is injected near the substrate surface. This inert gas blanket over the target surface is helpful in reducing target poisoning. 

It can be seen from the above discussion that target-gas plasma interaction during reactive sputtering leads to the formation of a compound layer on the target which Is termed as target poisoning. Numerous papers... 

Figure 10 Some techniques used to avoid target poisoning (34).

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