Targeted drug research

Polymers and copolymers are among the most beneficial materials produced by synthetic chemistry. The invention and commercialization of new polymeric materials with radical new properties provides an opportunity to monopolize the market and justify the expense involved in the research and development. The commercialization of new polymers or copolymers always presents scale-up and design challenges. Scientists have recently developed new polymeric materials whose commercial impact has yet to be realized. Examples are semiconductive and conductive polymers and amphiphilic dendritic block copolymers. Other promising materials, such as polymers for (targeted) drug delivery and... 

At the health care provider level, choices will be made among many therapeutic regimens that differ in effectiveness and cost. At the producer level, pharmaceutical companies must decide whether targeted drug development is economically feasible. Will there be a sufficient return on investment to justify the risks involved in pharmacogenomic research Will companies only pursue research and drug development for diseases for which there is... 

There have been excellent review articles related to the present topics (e.g. Muenchen and Pienta, 1999 Nelson et al, 2004, Inche and La Thangue, 2006). Our review has provided an overview of the research activities to understand the molecular basis of the function of the various classes of DNA-targeting drugs at... 

R. A. Glennon (1987). Central serotonin receptors as targets for drug research. J. Med. Chem. 30 1-12. 

Historically, the major focus of peptidomimetic design has evolved from receptor-targeted drug discovery research and has not been directly impacted by an experimentally-determined 3D structure of... 

Leurs, R. Timmerman, H. The histamine H3 receptor a target for developing new drugs. In Progress in Drug Research Jucker, E. Ed. Birkhauser Verlag Basel, 1992 Vol. 39. pp. 127-165. 

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