Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Target-oriented library

We anticipate that the current shift in combinatorial chemistry libraries away from numerically large to more focused, target-oriented libraries will continue in the near future and that these hbraries will be helpful in developing ligands with improved binding characteristics. It is also plausible that such a shift may open efficient inhibitor and ligand discovery opportunities to academic laboratories. [Pg.130]

Centerpieces of combinatorial concepts include the synthesis of compound libraries instead of the preparation of single target compounds. Library synthesis is supplemented by approaches to optimize the diversity of a compound collection (diversity-oriented synthesis) and by efforts to create powerful interfaces between combinatorial synthesis and bioassays. [Pg.381]

Zheng, W. and Lampe, J. (2002) Combinatorial optimization approaches to the design of focused, diverse, and target class oriented libraries. Cambridge Healthtech Institute s Sixth Annual Cheminformatics, Philadelphia, PA. [Pg.398]

Rosania et al. [19] have shown this straightforward preparation to be advantageous for the transposition to a diversity-oriented, combinatorial approach to an organelle-targeted fluorescent library. Therefore, the condensation of 9 and 10 (Fig. 5.4) with pyrrolidine as a catalyst was performed in 96-well plates and the dehydration reaction was accelerated by microwave irradiation for 5 min to give 10-90% conversion. The resulting library compounds were analyzed using an LC-MS system with diode-array and fluorescence detectors and a fluorescence plate-reader to determine the absorption and emission maxima and the emission colors. [Pg.185]

The Ugi four-component reaction is currently the most investigated MCRs in both target-oriented [95] as well as diversity-oriented S3mthesis of compound libraries (for reviews, see [33-52]). As one of the rare truly and highly versatile... [Pg.11]

Fig. 17.3 Target-oriented approach and diversity-oriented fluorescence library approach... Fig. 17.3 Target-oriented approach and diversity-oriented fluorescence library approach...
The power of furan has long been appreciated in target-oriented synthesis and more recently in diversity-oriented synthesis. Schreiber has made elegant use of the embedded diversity in this heterocycle to build complex, natural product-like libraries <03SCI1613 04JA14095> (Scheme... [Pg.28]

Figure 4.1. Planning strategies and end goals involved in target-oriented synthesis, focused library synthesis (combinatorial synthesis), and diversity-oriented synthesis. The first two approaches use retrosynthetic analysis to design the synthesis of target compounds. Diversity-oriented synthesis uses forward synthetic analysis to produce libraries that occupy diffuse regions of chemical space. Figure 4.1. Planning strategies and end goals involved in target-oriented synthesis, focused library synthesis (combinatorial synthesis), and diversity-oriented synthesis. The first two approaches use retrosynthetic analysis to design the synthesis of target compounds. Diversity-oriented synthesis uses forward synthetic analysis to produce libraries that occupy diffuse regions of chemical space.

See other pages where Target-oriented library is mentioned: [Pg.69]    [Pg.168]    [Pg.168]    [Pg.124]    [Pg.69]    [Pg.168]    [Pg.168]    [Pg.124]    [Pg.315]    [Pg.459]    [Pg.116]    [Pg.81]    [Pg.469]    [Pg.585]    [Pg.142]    [Pg.146]    [Pg.98]    [Pg.580]    [Pg.419]    [Pg.422]    [Pg.438]    [Pg.483]    [Pg.838]    [Pg.260]    [Pg.117]    [Pg.576]    [Pg.240]    [Pg.245]    [Pg.248]    [Pg.8]    [Pg.9]    [Pg.10]    [Pg.52]    [Pg.100]    [Pg.114]    [Pg.248]    [Pg.226]    [Pg.287]    [Pg.133]    [Pg.134]    [Pg.508]    [Pg.382]   
See also in sourсe #XX -- [ Pg.124 , Pg.130 ]




SEARCH



Library targeted libraries

Target libraries

Target, targets libraries

Targeted libraries

© 2024 chempedia.info