Target-organ damage

Regardless of the initiating process or processes leading to the development of hypertension, the ultimate goal is to reduce the risk of cardiovascular events and minimize target organ damage. This clearly requires the early identification of risk factors and treatment of patients with hypertension. 

What signs of target organ damage does JT exhibit ... 

SLE Systemic lupus erythematosus TOD Target-organ damage... 

If discontinued, therapy should be restarted if blood pressure exceeds 150 to 160 mm Hg systolic or 100 to 110 mm Hg diastolic or if target-organ damage is present. 

Severe hypertension Severe hypertension that is symptomatic or associated with target organ damage, and is not manageable with maximum therapeutic doses of a diuretic plus two other antihypertensives. 

Target organ damage/clinical cardiovascular disease Heart diseases... 

SBP) was seen with candesartan, and the smallest with eprosartan. The control of SBP attracts more attention from the fact that SBP is more closely related to target organ damage than DBP. The beneficial effects of ARBs in patients with isolated systolic hypertension have been well-documented by the LIFE (losartan), Val-Syst (valsartan), and SCOPE (candesartan) studies [26-28]. 

The patient may have a previous medical history or diagnostic findings that indicate the presence of hypertension-related target-organ damage ... 

Heart disease is the most well-identified form of target-organ damage. A thorough cardiac and pulmonary examination can identify cardiopulmonary abnormalities. Clinical manifestations include left ventricular hypertrophy, coronary heart disease (e.g., angina, prior myocardial infarction, and prior coronary revascularization), and heart failure. These complications may lead to cardiac arrhythmias, angina, myocardial infarction, and sudden death. Coronary heart disease and associated cardiac events are the most common causes of death in hypertensive patients. 

The peripheral vasculature is considered a target organ. Physical examination of the systemic vasculature can detect evidence of atherosclerosis, which may present as bruits (in the aortic, abdominal, and peripheral arteries), distended veins, diminished or absent peripheral arterial pulses, or lower extremity edema. Peripheral arterial disease is a clinical condition that can result from atherosclerosis, which is accelerated in hypertension. Other cardiovascular risk factors (e.g., smoking) can increase the hkelihood of peripheral arterial disease as well as all other forms of target-organ damage. 

---