Tandem organic reactions Diels-Alder reaction

Nicolaou, K. C., Li, J. "Biomimetic" cascade reactions in organic synthesis construction of 4-oxatricyclo[4.3.1.0]decan-2-one systems and total synthesis of 1-O-methylforbesione via tandem Claisen rearrangement/Diels-Alder reactions. Angew. Chem.. Int. Ed. Engl. 2001,40, 42644268. 

The domino cycloaddition-iV-acyliminium ion cyclization cascade has been extensively reviewed. Tandem reactions combining Diels-Alder reactions and sigma-tropic rearrangement reactions in organic synthesis have been extensively reviewed. The tandem Diels-Alder reaction between acetylenedicarboxaldehyde and N,N -dipyrrolylmethane has been extensively studied at the RHT/3-21G and RHF/6-31G levels.The molecular mechanism of the domino Diels-Alder reaction between hexafluorobut-2-yne and A,A -dipyrrolylmethane has been studied using density functional theory. 

Cross-conjugated trienes are useful building blocks for organic synthesis. It has been shown that cross-conjugated trienes can be used in tandem Diels-Alder reactions, forming the unsaturated decalin ring (Figure 2-17). ... 

The Diels-Alder reaction of ester-tethered trienes is also known as a powerful methodology to construct polycylic Y lactones [68]. Romo et al. [69] surveyed effective organic nucleophilic catalysts for tandem intermolecular Diels-Alder reaction/lactonization reaction of achiral a, 3-unsaturated acid chlorides with dienyl alcohol 100 (Scheme 45). In this case, when chiral Lewis base 102 was used as a nucleophilic catalyst, excellent enantioselectivity was realized. Lipase-catalyzed domino kinetic resolution/intramolecular Diels-Alder reaction of furfuryl alcohols with acrylic acids was also carried out by Akai and Kita [70]. 

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