Tailor-made dendrimer

The combination of the above techniques with TLC, HPLC, UV-vis spectroscopy, and other emerging spectroscopic tools demonstrates that the abihty to construct a wide variety of different dendritic structures is matched by the ability to determine accurately and confirm those structures. This permits the purposeful design and preparation of tailor-made dendrimers with a degree of structural confidence that is unparalleled in synthetic polymer chemistry. 

Fig. 6.10 Glycinylurea guest molecules (green) dock onto the urea-functionalised, niche-like periphery (red) of a POPAM dendrimer (shown schematically as grey sphere, with 32 terminal groups) owing to tailor-made supramolecular interactions (red bonds) (according to Meijer el al.)...

Keywords Biocompatible hydrogels Complex architectures Functionalized vinyl monomers lanus-type dendrimers Modular nature Passerini three-component reaction PEGylation of proteins Photo-responsive polymers Sequence-defined structures Tailor-made materials Ugi four-component reaction... 

Dendrimers are hyper-branched nano-structures, made by a large number of (one or more types) substructures called monomers, synthetically joined within a rigorously tailored architecture (TomaUa et al. 1990 Newkome et al. 2(X)1 Diudea and Katona 1999). They can be functionalized at terminal branches, thus finding a broad pallet of applications in chemistry, medicine, etc. 

In particular, the review by Tomalia et al. [124] traces the similarities and scope of the dendrimer designs to biological systems tailored by Mother Nature and the prospects and applications of supramolecular mimetics via man-made... 

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