Tadalafil efficacy

Gresser U, Gleiter CH. Erectile dysfunction comparison of efficacy and side effects of the PDE-5 inhibitors sildenafil, vardenafil and tadalafil review of the literature. Eur J Med Res 2002 7 435-446. 

TADALAFIL 10 mg taken prior to anticipated sexual activity. The dose may be increased to 20 mg or decreased to 5 mg, based on individual efficacy and tolerability. The maximum recommended dosing frequency is once daily in most patients. Tadalafil may be taken without regard to food. 

The following groups of patients with cardiovascular disease were not included in clinical safety and efficacy trials for tadalafil, and, therefore, the use of tadalafil is not recommended in these groups until further information is available ... 

Tadalafil has also been extensively evaluated in patients with cardiovascular disease and has a similar safety and efficacy profile to sildenafil (45). Studies have shown no adverse effects on cardiac contraction, ventricular repolarization, or ischemic threshold. A similar hypotensive effect has been recorded with a dose of doxazosin 8 mg so caution is needed. As hypotension does not occur in the supine position and as tadalafil has a long half-life it is suggested that tadalafil is taken in the morning and doxazosin in the evening. There is no interaction of tadalafil with the selective a-adrenoceptor antagonist tamsulosin, which can, therefore, be prescribed as an alternative to doxazosin for symptomatic benign prostate hypertrophy (46). 

McMahon C, Comparison of efficacy, safety, and tolerability of on demand tadalafil and daily dosed tadalafil for the treatment of erectile dysfunction, J Sex Med 2006 2 4I 5 -24,... 

PHOSPHODIESTERASE TYPE 5 INHIBITORS (e.g. sildenafil, tadalafil, vardenafil) GRAPEFRUIT JUICE Possibly t efficacy and t adverse effects, e.g. hypotension Small t in bioavailability, t variability in pharmacokinetics, i.e. interindividual variations in metabolism Safest to advise against intake of grapefruit juice for at least 48 hours prior to intending to take any of these preparations. When necessaiy, the starting dose of sildenafil should not exceed 25-50 mg and that of tadalafil 10 mg. Avoid co-administration with vardenafil... 

Efficacy and safety of tadalafil for the treatment of erectile dysfunction [56]... 

Porst H, Padma-Nathan H, Giuliano E, et al. Efficacy of tadalafil for the treatment of erectile dysfunction at 24 and 36 hours after dosing A randomized controlled trial. Urology 2003 62 121-126. 

Tadalafil has recently been approved with data showing efficacy at the 40 mg once daily dosing (two 20 mg tablets) (105). 

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