Tacrine Theophylline

Drugs that may be affected by SSRIs Drugs that may be affected by SSRIs include alcohol, benzodiazepines, beta blockers, buspirone, carbamazepine, cisapride, clozapine, cyclosporine, diltiazem, digoxin, haloperidol, hydantoins, lithium, methadone, mexiletine, nonsedating antihistamines, NSAIDs, olanzapine, phenothiazines, phenytoin, pimozide, procyclidine, ritonavir, ropivacaine, sumatriptan, sulfonylureas, sympathomimetics, tacrine, theophylline, tolbutamide, tricyclic antidepressants, and warfarin. 

Smoking cessation, with or without nicotine substitutes, may alter response to concomitant medication in ex-smokers. Smoking may affect alcohol, benzodiazepines, beta-adrenergic blockers, caffeine, clozapine, fluvoxamine, olanzapine, tacrine, theophylline, clorazepate, lidocaine (oral), estradiol, flecanide, imipramine, heparin, insulin, mexiletine, opioids, propranolol, catecholamines, and cortisol. 

CYP1A2 Acetaminophen Antipyrine Caffei ne Tacrine Theophylline R-Warfarin... 

When Hie cholinesterase inhibitors are administered with the anticholinergic drugp, there is a potential decrease in activity of the anticholinergic drug. There is an increased risk of toxicity of theophylline when the cholinesterase inhibitors are administered with tacrine There is a synergistic effect when tacrine is administered with succinyl-choline, cholinesterase inhibitors, or cholinergic agonists (eg, bethanechol). 

Naproxen Olanzapine Tacrine Tertiary TCAs Theophylline Warfarin Type 1C antiarrhythmics Codeine Erythromycin Estrogen Quinidine Phosphodiesterase-5 inhibitors Protease inhibitors TCAs Terfenadine Zolpidem... 

Drugs that may be affected by tacrine include anticholinergics, cholinomimetics, cholinesterase inhibitors, and theophylline. 

A2 Acetaminophen, antipyrine, caffeine, clomipramine, phenacetin, tacrine, tamoxifen, theophylline, warfarin Smoking, charcoal-broiled foods, cruciferous vegetables, omeprazole Galangin, furafylline, fluvoxamine... 

Compound Nitrofurazone Sodium Ascorbate Ethyl Gallate Guaiphenesin Metharbitone Theophylline Hydrate Guanethidine Tacrine... 

Tacrine may increase plasma levels of drugs metabolized by CYP4501A2 (e.g., theophylline) and require dose adjustment... 

CYP1A2 Antidepressants amitriptyline, clomipramine, imipramine, fluvoxamine Neuroleptics haloperidol, phenothiazines, thiothixene, clozapine, olanzapine Others tacrine, caffeine, theophylline, acetaminophen, phenacetin No report of polymorphism until 1999 significance of following findings remains unclear 1C reduced activity 23% in Japanese 1F higher inducibility 32% in Caucasians... 

Acetaminophen, acetanilide, aminopyrine, antipyrine, aromatic amines, chlorzoxazone, clozapine, 17/3-estradiol, flutamide, imipramine,lidocaine,((S)-and (i )-mianserin, (S)- and (J )-naproxen, phenacetin, propafenone, tacrine, tamoxifen, theophylline, trimethadone, verapamil, (7 )-warfarin, zolpidem... 

Because of its mechanism of action, tacrine has the potential to interfere with the activity of anticholinergic medications. A synergistic effect is expected when tacrine is given concurrently with succinylcholine, cholinesterase inhibitors, or cholinergic agonists, such as bethanecol. Coadministration of tacrine with theophylline increases theophylline elimination half-life and average plasma concentrations. 

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