Tacrine Succinylcholine

Anesthesia Tacrine is likely to exaggerate succinylcholine-type muscle relaxation during anesthesia. 

This entry focuses on ChE inhibitions by OPs and CBs. Other chemicals, such as tacrine, cocaine, and succinylcholine, are briefly discussed. 

Clinically important, potentially hazardous interactions with bethanechol, cimetidine, donepezil, edrophonium, physostigmine, pilocarpine, rivastigmine, succinylcholine, tacrine... 

Because of its mechanism of action, tacrine has the potential to interfere with the activity of anticholinergic medications. A synergistic effect is expected when tacrine is given concurrently with succinylcholine, cholinesterase inhibitors, or cholinergic agonists, such as bethanecol. Coadministration of tacrine with theophylline increases theophylline elimination half-life and average plasma concentrations. 

Oberoi GS, Yaubihi N. The use of tacrine (THA) and succinylcholine compared with alcuio-nium during laparoscopy. P NGMedJ (1990) 33,25-8. 

Davies-Lepie SR. Tacrine may prolong the effect of succinylcholine. Anesthesiology (1994)... 

El-Kammah BM, El-Gafi SH, El-Sherbiny AM, Kader MMA. Biochemical and cUmcal stwfy for the role of tacrine as succinylcholine extender. J Egypt Med Assoc (1975) 58,559-67. Crowe S, Collins L. Suxamethonium and donepezil a cause of prolonged paralysis. 

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