Tablet crushing strength

Fig. 27 Methods of evaluating tablet crushing strength (a) bending or flexure strength (b) diametrical compression. (From Ref. 145.)...

Fig. 7 Relation of tablet crushing strength and surface area of selected size fractions of anhydrous a-lactose, which had been compressed at 37.5 mPa. Data are shown for initial size fractions of (A) 24-32 /am, (B) 32-63 /am, (C) 63-100 /am, (D) 100-160 /am, (E) 160-200 /am, and (F) 250-315 /am. (Data adapted from Ref. 51.)...

FIGURE 2.46 Effect of the particle size of the coprocessed excipient of chitin-mannitol on tablet crushing strength, disintegration time, and friability prepared from this excipient. The tablets were 9 mm in diameter and 180 mg in weight. All samples were lubricated with 0.5% (w/w) magnesium stearate. 

Bolhuis, G.K. deJong, S.W. Lerk, C.F. The effect of magnesium stearate admixing in different types of laboratory and industrial mixers on tablet crushing strength. Drug Devel. Ind. Pharm. 1987,13, 1547. 

Tablet crushing strength of isomalt GalenlQ 720, Palatinit GmbH).

Compaction simulators are most commonly used to replicate the compaction process of a rotary tablet press. Manufacturing parameters, such as production speed, dwell lime, compression force, precompression force are often studied using a relatively small quantity of bulk powder. These parameters can significantly affect tablet crushing strength, friability, and disintegration time. The relationship among compaction pressure. 

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