Systemic inflammatory response syndrome clinical manifestations

Systemic inflammatory response syndrome The systemic inflammatory response to a wide variety of severe clinical insults. The response is manifested by two or more of the following conditions Temperature >38°C or <36°C Heart rate >90 beats/min... 

Pathological findings frequently observed in organs of patients who have died of sepsis include disseminated intravascular coagulation (DIC), manifested as diffuse thrombotic occlusions in the entire microvascular system, associated with alterations in the hemostatic mechanism and clinical signs of hemorrhagic diathesis. Many observations indicate that DIC contributes to the major symptoms of the systemic inflammatory response syndrome (SIRS), which frequently complicate sepsis (HI, H2, H3, T6). 

Whereas LPS itself is chemically inert, the presence of LPS in blood (endotox-emia), often a consequence of antibiotic therapy of preexisting bacterial infections, sets off a cascade of exaggerated host responses, which, under normal, homeostatic conditions, serve to orchestrate innate immune defenses. It is the uncontrolled, overwhelming, and precipitous systemic inflammatory response that ultimately manifests clinically in the frequently fatal shock syndrome characterized by... 

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