Synthetic organic chemistry, connections

In Chapter 4, on molecular symmetry, 1 have added two new sections. One of these concerns the relationship between symmetry and chirality, which is of great importance in synthetic organic chemistry. The other relates to the connection between the symmetry of a molecule and whether it has a permanent dipole moment. 

The question of protonation sites is one of the basic questions in the behaviour of complex organic molecules in solution, since protonated molecules are intermediates in synthetic organic chemistry, and the knowledge of protonation sites is important for the theory of reaction mechanisms of acid-catalysed reactions. It is also of fundamental importance for structural theory in general, since it is intimately connected with the concepts of mesomerism, electron density and bond polarization. 

From the very beginning of synthetic organic chemistry, studies have been intrinsically connected to natural products from varying sources. In contrast to... 

The hydrolysis of a carboxylic acid derivative is but one example of a nucleophilic acyl substitution. Nucleophilic acyl substitutions connect the various classes of carboxylic acid derivatives, with a reaction of one class often serving as preparation of another. These reactions provide the basis for a large number of functional group transformations both in synthetic organic chemistry and in biological chemistry. 

The preparation of chiral compounds is an important and challenging area of contemporary synthetic organic chemistry, mainly in connection with the fact that most natural products are chiral and their physiological or pharmacological properties depend on their recognition by chiral receptors, which will interact only with molecules of the proper absolute configuration. 

Amino-ketones are important intermediates in synthetic organic chemistry and are also biologically important substances. A new, simple, and efficient synthesis of a-dialkylamino-ketones from aldehydes and secondary amines utilises a C—C connective strategy, and offers regioselectivity via synthon control (Scheme 21). A synthesis of 2-dialkylamino-6-alkylcyclohexanones from 2-alkyl-2-chlorocyclohexanones has also been reported. ... 

HPTLC is a very fast and convenient assay to separate samples components and is often used in Organic Chemistry and in Synthetic approach. Unknown substances, after different display assay, were generally scraped off from the TLC/HPTLC plate, diluted into a tube and transferred into the MS system for structural elucidation and characterization. Now, a TLC-MS interface was developed by CAMAG, which can semi-automatically extract zones of interest and on-line direct them into any brand of a HPLC-MS system. The TLC-MS interface is connected by two fittings to any HPLC instrument coupled with mass spectrometer, without other system configuration adjustments or mass spectrometer modifications. By this way, the unknown substances can be directly extracted from a TLC/HPTLC plate, eluted and resolved by HPLC system and sensitive and selective mass spectrometric signals are obtained within a minute per substance zone [33],... 

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