Synthetic enzymes, rational design

Riley, D.P. Rational design of synthetic enzymes and their potential utility as human pharmaceuticals development of manganese(II)-based superoxide dismutase mimics. Adv. Supramol. Chem. 2000, 6, 217-244. 

Stereoselective catalysis using biocatalysts (e.g. enzymes) and also of rationally designed small chiral molecules, deals essentially with the same principle the spatial and selective docking of guest molecules to a chiral host molecule to form complementary interactions to form reversible transient molecule associates (see the specific sections in this volume). The enantiomeric excess of a certain reaction and hence the result will be determined by the degree of chiral discrimination. Along the same theoretical lines the concepts of protein (enzyme, antibody, etc.) mimicks via imprinted" synthetic polymers should be mentioned and will be discussed further. 

RATIONAL DESIGN OF SYNTHETIC ENZYMES AND THEIR POTENTIAL UTILITY AS HUMAN PHARMACEUTICALS ... 

In order to better understand the effects that substituents exert, we utilized a combination of molecular mechanics calculations and synthesis with the goal of rational design of highly substituted chemically stable synthetic enzymes. It needs to be stressed that while the prediction of properties and reactivity of small... 

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