Estrogens, synthetic conjugated

Synthetic conjugated estrogens 03, 0.45, 0.625,0.9, 1.25 mg late synthesis of hepatic proteins... 

CENESTIN (Duramed) (synthetic conjugated estrogens) February 2004 labeling... 

Conjugated equine estrogens Synthetic conjugated estrogens bterified estrogens Estropipate (piperazine estrone sulfate)... 

Estrogen is indicated in the treatment of moderate to severe symptoms associated with menopause (synthetic conjugated estrogens, A or B) moderate to severe symptoms of vulvar and vaginal atrophy (synthetic conjugated estrogens A, 0.3 mg only). 

Approximately 50% of a dose of mestranol is de-methylated to form ethinyl estradiol. Ethinyl estradiol also can be deethinylated. Subsequently, the metabolism of these two synthetic estrogens proceeds by means of the same pathways as the natural steroid hormones. The principal metabolites of mestranol and ethinyl estradiol are hydroxylated derivatives that are conjugated with either glucuronic acid or sulfate. The synthetic steroid estrogens, in contrast to the natural estrogens, are excreted primarily in the feces. 

Estrone, USP. Estrone, 3-hydroxyestra-l,3,S(IO)-tricn-17-one, is less active than estradiol but more active than its metabolite, estriol. As the salt of its 3-sulfate ester, estrone is the primary ingredient in conjugated estrogens, USP, and esterifled estrogens, USP. Although originally obtained from the urine of pregnant marcs (about 10 mg/L). estrone is now prepared synthetically. 

Chem. Common. 1967, 1253 Marshall, Deghenghi, Can, J Chem. 47, 3127 (1969). Component of Conjugated Estrogenic Hormones, q.v. Review of synthetic studies Taub, "Naturally Occurring Aromatic Steroids in The Total Synthesis of Natural Products vol, 2, J. ApSimon, Ed. (John Wiley Sons. New York, 1973) pp 664-670,... 

Compare the naturally and synthetically derived conjugated estrogens. 

Natural conjugated estrogens are derived from equine urine. The proportions and concentrations of the various estrogens are unpredictable. The synthetic conjugated products are derived from plants (e.g., soy, yams) and contain a more clearly defined population of estrogens in proportions that are also more clearly defined. The two preparations appear equipotent with regard to physiologic effects. 

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