Synthesizer Nautilus

The synthesis can be carried out manually or automated using a Symphony/Multiplex multiple peptide synthesizer or an Argonaut Nautilus. 

The Nautilus 2400 Synthesizer [16, 17] (Figure 13.6) is engineered as a closed-to-the-outside-atmosphere fluid delivery system. It is the first commercially available synthesizer of organic compounds that is not based on a robotic system. 

Synthesized compounds can be cleaved from the resin and delivered to any of the positions of the integrated fraction collector. Development of different challenging chemistries on the Nautilus 2400 Synthesizer has been recently reviewed [18]. 

The Nautilus 2400 synthesizer (Fig. 35) is a highly sophisticated instrument designed to carry out parallel synthesis of 24 compounds [89,90], It is also very useful for chemistry optimization. The instrument contains six modules an autosampler, the Reagent Solvent Enclosure, the Reaction Vessel Enclosure, a gas chiller, and a computer. 

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