Synthesis utilisation

The synthesis of duplex DNA containing a spin-labelled analogue of 2 -deoxycytidine has been reported.The synthesis utilised the reagent 224. 

The first asymmetric synthesis of a 7,1 linked alkaloid was that of (-)-dioncophylline A (8) (triphyophylline) which resulted in the revision of the initially proposed stereostructure (ref. 77). The synthesis utilised the intramolecular approach that was successful for the synthesis of racemic 8 (see Scheme 7) and began with the production of optically pure tetrahydroisoquinoline 79... 

An alternative base labile 5 -protecting group, 2-dansylethoxycarbonyl (111) has been proposed for RNA synthesis utilising tetrahydro-4-methoxy-2H-pyran-4-yl for 2 -protection, 2-(4-nitrophenyl)ethyl and 2-(4-nitrophenyl)ethoxycarbonyl for phosphate and amino group masking. 

Allan J. Canty, Thomas Rodemann, and John H. Ryan, Transition Metal Organometallic Synthesis Utilising Diorganoiodine(HI) Reagents. . . Al-Ahmad, Saleem, see Ashe, Arthur J., HI... 

Most methods of diphosphine complex synthesis utilise preformed P-P bonds (8.230) and (8.232). Further heating of these complexes may break the P-P bonds (8.231). 

This enzyme is a biotin protein. It also catalyses transcarboxylation reactions. The reaction shown here is an important step in fatty acid synthesis utilising malonyl CoA as an intermediate. It may be assayed radiochemically using C labelled KHCO3 in a reaction which is stopped by the addition of 6 N HCl [180]. 

A second major approach to semi-synthetic cephamycin synthesis utilises carbanion formation a to the P-lactam carbonyl. Reaction with electrophiles then provides substrates suitable for the introduction of the methoxy group. Several papers have described how the anion generated from the SchifPs base (220 =60 ) reacts readily with methyl methan-... 

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