Synthesis 178-9 structure design

In 2002, Hoveyda et al. reported the synthesis, structure and reactivity of a chiral bidentate Ru-based catalyst 65, bearing a binaphthyl moiety, for olefin metathesis [33]. Preference for a bidentate chiral imidazolinylidene was based on the hypothesis that such a ligand would induce chirality more efficiently. This catalyst was designed by analogy with similar achiral complexes 66 that... 

The objective of traditional multistep synthesis is the preparation of a single pure compound, but combinatorial synthesis is designed to make many related molecules.57 The purpose is often to have a large collection (library) of compounds for evaluation of biological activity. A goal of combinatorial synthesis is structural diversity, that is, systematic variation in subunits and substituents so as to explore the effect of a range of structural entities. In this section, we consider examples of the application of combinatorial methods to several kinds of compounds. 

The QSAR (4) cannot only highlight structural factors most likely to impact positively or negatively upon their biological activity, it can be used to probe drug-DNA interactions. QSAR (4) has already enabled identification of candidates with reasonable anticancer activity and can direct future synthesis and design to this end. 

Department of Organic Chemistry, NSR Center for Molecular Structure, Design and Synthesis, University of Nijmegen, Toernooiveld, 6525 ED Nijmegen, The Netherlands... 

A substantial effort in our laboratory has been directed toward the synthesis and characterization of acetylene-terminated (AT) matrix resins. The most significant feature and driving force for the effort is that the thermal induced addition reaction provides a moisture Insensitive cured product. This technology offers a wide variety of thermoset resins for various high temperature applications. Backbone structural design for use temperature capabilities, processing characteristics and mechanical performance has demonstrated the versatility of the AT type systems. 

Summarizing, there are still many scientific challenges and major opportunities for the catalysis community in the field of cobalt-based Fischer-Tropsch synthesis to design improved or totally new catalyst systems. However, such improvements require a profound knowledge of the promoted catalyst material. In this respect, detailed physicochemical insights in the cobalt-support, cobalt-promoter and support-support interfacial chemistry are of paramount importance. Advanced synthesis methods and characterization tools giving structural and electronic information of both the cobalt and the support element under reaction conditions should be developed to achieve this goal. 

Whilst there have been a number of excellent reviews on the design, synthesis, structural determination, and photophysics of luminescent lanthanide complexes (1-6), detailed information for coordination chemists on how these compounds may be used as analytes in the biochemical and biological sciences has been somewhat less readily... 

Polyanilines. Initial preparations of polyaniline (PANI) led to insoluble materials that were difficult to characterize. Use of model compounds and polymers (124,125) allowed for definitive structural analysis. Poly(/>-phenylene amineimine) (PPAI) was synthesized direcdy to demonstrate that PANI is purely para-linked (126). The synthesis was designed so as to allow linkage through the nitrogen atoms only (eq. 9). Comparison of the properties of PPAI and PANI showed PPAI to be an excellent model both structurally and electronically. 

K. Johnsson, R. K. Allemann, H. Widmer and S. A. Benner, Synthesis, structure and activity of artificial, rationally designed catalytic polypeptides, Nature 1993, 365, 530-532. 

Study of synthetic analog for the active sites in metalloproteins (design, synthesis, structure, spectroscopy, and applications like metal sequestering from waste water and deposits, catalytic reactions)... 

R.D. Bartusiak, C. Georgakis, and M.J. Reilly. Nonlinear feedforward/feedback control structures designed by reference synthesis. Chemical Engineering Science, 44 1837-1851, 1989. 

The explosion of new aminoindanol-derived ligands disclosed in the past few years is the unmistakable mark of recognition and appreciation of the indanyl platform as a valuable backbone in the field of catalytic asymmetric synthesis. The emergence of related and novel structural designs and their success in achieving improved selectivities clearly reveal the continuing interest in the synthetic potential of conformationally constrained amino alcohols. 

Materials chemistry contains all the elements of modem chemistry. These include synthesis, structure, dynamics, and properties. In synthesis, one employs all possible methods and conditions from high-temperature and high-pressure techniques to mild solution methods (chimie douce or soft chemistry).3 Chemical methods generally tend to be more delicate, often yielding novel, metastable products. Kinetic rather than thermodynamic control of reactions favors the formation of such structures. Supramolecular organization provides new ways of designing materials. 

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