Synthesis reductive coupling

Synthesis reductive coupling of dihalogenophenyl compounds in the presence of Ni complexes [704-706] or oxidative coupling of cation radicals originating from either benzene or biphenyl species in weakly nucleophilic media [708], Highly crystalline PPP films have been prepared by electrochemical oxidation from ben-zene/96% H2SO4 solution [706,707],... 

Keywords Photocatalytic Organic synthesis reduction Coupling reactions... 

An unprecedented nickel-catalyzed reductive coupling between an epoxide and an alkyne to give synthetically useful homoallylic alcohols has been developed by Jamison [55a], and was recently used in a short enantioselective synthesis of am-... 

Scheme 9 Synthesis of enantiopure piperazines by reductive coupling of chiral 2,5-diaza-1,5-dienes...

The asymmetric synthesis of unsymmetrical vicinal diamines by samarium diiodide induced reductive coupling of nitrones derived from aUphatic aldehydes with optically pure N-tert-butanesulfinyl aromatic imines has been recently reported [41]. For example, the reaction between nitrone 55 and... 

These methods were applied to the synthesis of heterocycles such the per-hydroindene in Eq. 3 [17]. The reductive coupling of diene 24 catalyzed by Cp2ZrCl2 in the presence of BuMgBr demonstrates the ability of the coupling to generate contiguous stereogenic centers in an effective fashion. 

The palladium-catalyzed reductive coupling reactions were used in the synthesis of several natural products, including laurene [75], ceratopicanol [80], and dihydrostreptazolin 141 [81]. The cyclization leading to dihydrostrepta-zolin shown in Eq. 26 highlights the diastereoselectivity and functional group compatibility seen with this catalytic system. 

The presence of alkali metal during reductive coupling practically prevents the synthesis of polysilanes with groups which can be easily cleaved under basic conditions, such as pendant alkoxy or amino substituents. Polysilanes with pendant functional groups are not known. We have recently discoverd a very efficient method of functionalization of polysilanes. 

Matyjaszewski Krzysztof, Dorota Gresta, Hrkach Jeffrey S, Hwan Kyu Kim (1995) Sono-chemical synthesis of polysilylenes by reductive coupling of disubstituted dichlorosilanes with alkali metals. Macromolecules 28 59-72... 

Scheme 5.12 Synthesis of C-ring fragment 69 via hydrogen-mediated reductive coupling...

McMurry, J. E., and M. P. Fleming. 1974. A new method for the reductive coupling of carbonyls to olefins Synthesis of /3-carotene. J. American Chemical Society 96 4708-9. 

Another possibility for creating a new ligand structure is to connect two phos-phaferrocene molecules via their formyl functional groups. The reductive coupling of carbonyl compounds with low-valent Ti reagents - the McMurry reaction - is a technique that has found wide application in organic synthesis [18]. 

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