Synthesis of Thioureas

The synthesis of thioureas has been accomplished in several manners by using isothiocyanate, carbon disulfide, hydrogen sulfide and KSCN (potassium thiocyanate). 

Thioamides, Thioureas and Related Selenium and Tellurium Compounds 

Reaction of isothiocyanate with amine gives the corresponding thioureas. 

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Synthesis of Thiourea-Bridged Glycosides from Glycosyl Isothiocyanates... 

Three categories of agents against the human immunodeficiency virus (HIV) are nucleoside analogues, protease inhibitors, such as thiourea derivatives. Therefore, Le and his coworkers developed a simple, mild, and efficient method for the synthesis of thiourea derivatives via the reaction of phenyl isothiocyanate and amines in [bmim][BF ] (Fig. 12.2) [2]. The method is also useful for the preparation of... 

The equilibrium mixture of these two compounds can be directly used for the preparation of sugar-derived thioureas by coupling with alkyl and aryl amines [47]. This was the first example in the literature of a thio carbamate acting as a latent isothiocyanate for the synthesis of thioureas. 

Time-resolved Raman spectra for (A) the LAG synthesis of thiocarbamoyl benzotriazole 64 and (B) the LAG synthesis of thiourea 65 using sodium carbonate as the base (HBt= IH-benzotriazole). 

Facile mechanochemical synthesis of thioureas was developed by Strukil et al. (Scheme 3.46) [32], Formation of new thioamide C—N bond was achieved by reaction of aromatic isothiocyanates 166 with aromatic amines (Table 3.20). Addition of small amount of methanol (LAG) was beneficial and the high yields were obtained regardless on the reactant physical state. The whole synthesis was carried out without the use of bulk organic solvents, that is solvent-free mechanosynthesis was quantitative, which voids the use of solvent for purification. Mechanochemical reaction... 

Synthesis.—Very few examples of the synthesis of thioureas by thionation of the corresponding ureas using phosphorus pentasulphide, especially in the case of open-chain thioureas, were known prior to the period covered by this review. Voss found it expedient to subject this reaction to a... 

Both Zwelling and coworkers (63) and Filipski and coworkers (64) have demonstrated that the addition of thiourea subsequent to cis-DDP treatment leads to a reversal of DNA-cis-DDP crosslinks. Thus, synthesis of thiourea derivatives of cis-DDP may result in polymer with decreased toxicity, yet sufficient antitumoral activity. 

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