Synthesis Martin

P Volume 1,1991,283 pp. 109.50/ 69.50 ISBN 1-55938-180-9 CONTENTS Introduction to the Series An Editor s Foreword, Albert Padwa. Preface, Brian Halton. Strain in Organic Chemistry A Perspective, Brian Halton. Gem-Dihalocyclopropanes in Chemical Synthesis, Martin G. Banwell and Monica E. Re-um. 1-Halo- and 1, 2-Dihalocyclopropenes Useful Synthetic Intermediates, Mark S. Baird. Cyciization and Cycloaddition Reactions of Cyclopropenes, Albert Padwa and Glen E. Fryx-ell. New Synthetic Pathways From Cyclobutanones, Edward Lee-Ruff. Cyclic Alkynes, Enynes and Dienynes A Synthetic Challenge, Herbert Meier. Index. 

Mammalian cells HeLa cells Unscheduled DNA synthesis - - Martin and McDermid 1981... 

Figure 13.13. SEM image of PPy nanofibers prepared by template synthesis. (Martin, C.R., Chemistry of Materials, 8,1739-1746,1996.)...

Martin has achieved the synthesis of lycoramine (59) via a Bischler-Napieralski cyclization of 58 in the final step of the synthesis. Treatment of 58 with POCI3 followed by NaBHi provided the natural product 59 in 68% yield. 

A concise total synthesis of the indole alkaloid dihydrocorynantheol (101) (Scheme 19), that features two RCM steps and a zirconocene-catalyzed carbo-magnesation [68], is a further example of Martin s interest in applying RCM as a key reaction for the construction of alkaloid frameworks [69]. The first RCM step was applied to bis-allyl amide 96. The resulting intermediate 97 was directly subjected to carbomagnesation and subsequent elimination to deliver 98 in 71% yield from 96. Amide 98 was then transformed into acrylamide 99 in... 

Scheme 19 Construction of key lactam 100 via two RCM steps and a zirconocene-mediated carbomagnesation in Martin s total synthesis of dihydrocorynantheol (101) [68]...

Also, a novel RCM-based approach to the 6-aza[3.2.1]bicyclooct-3-ene 103, and hence a formal total synthesis of the antitumor antibiotic (-)-peduncular-ine (104) (Scheme 20), was recently disclosed by Martin s group [70]. Initial ex-... 

Scheme 25 Sequential formation of 13- and 8-membered azacycles in Martin s total synthesis of ircinal A (129) and related manzamine alkaloids [78]...

Martin S. F. Strategies for the Synthesis of Heterocyclic Natural Products J. 

The synthesis and study of dendrimers is a relatively new branch of macro-molecular chemistry. It began in 1985 with the publication of two landmark papers (D.A. Tomalia, H. Baker, J. Dewald, J.M. Hall, G. Kallos, R. Martin and J. Ryder, Polym. J., 1985,17,117-132 and G.R. Newkome, Z. Yao, G.R. Baker and V.K. Gupta, J. Org. Chem., 1985, 50, 2003-2004), and has grown to become a very vibrant research field. The word dendrimer comes from the Greek word dendra, meaning tree, and was applied to these compounds by Tomalia et al. in their very first paper. Newkome s team, by contrast, called their molecules arborols from the Latin word arbor, which also means a tree. The term cascade molecule has also been used, but the word dendrimer is the one that is used most widely throughout the literature, and is also used in the present chapter. 

For a review of methods of synthesis of aldehydes, ketones and carboxylic acids by coupling reactions, see Martin, S.F. Synthesis, 1979, 633. 

For an improved procedure with amides, see Olah, G.S. Prakash, G.K.S. Arvanaghi, M. Synthesis, 1984, 228. See Martin, R. Romea, R Tey, C. Urpi, R Vilarrasa, J. Synlett, 1997, 1414 for reaction with an amide derived from morpholine and Grignard reagents, whch gives the ketone in good yield. See Kashima, C. Kita, I. Takahashi, K. Hosomi, A. J. Heterocyclic Chem., 1995, 32, 25 for a related reaction. 

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