Synthesis light-directed parallel

Light-Directed Parallel Synthesis of Up to 250 000 Different Oligopeptides and Oligonucleotides... 

Figure 1. Light-directed parallel synthesis of two dipeptides from two amino acids in two irradiation...

Fig. 2 Light-directed parallel chemical synthesis of peptides and oligonucleotides on solid supports of Affymetrix s DNA microarray [5, 6]. A photo-protected glass substrate is selectively exposed to UV light through a mask that contains the desired pattern (1). The deprotected areas are activated in step (2) followed by nucleoside incubation where chemical coupling occurs at activated positions (5). In step (4), a new mask pattern is applied. The coupling step is repeated in step (5). The deprotection and coupling process is repeated until the desired set of probes is obtained as shown in step (6)...

Fodor, S. P. (1991). Light-directed, spatially addressable parallel chemical synthesis. Science 251, 767-773. 

In-situ photofabrication of OND arrays involves light-directed, spatially addressable, parallel (combinatorial) chemical synthesis [35,43,66-68]. A surface, usually a sihcon wafer or a glass slide, is coated with hnker molecules... 

I-odor. S P A. 01 at. "Light-Directed. Spatially Addressable Parallel Chemical Synthesis.". Vcienee, 767 (February IS. 19911 Jam>ld. M.F. "Nanosurfaee Clietnisiry on Size-Selected Silicon C liniers." Seitner. 1085 tMay 14. 1991). 

Eodor SP, Read JL, Pirrung MC, Stryer L, Lu AT, Solas D. Light-directed spatially addressable parallel chemical synthesis. Science 1991 25 767-773. 

Gao X, Zhou X, Gulari E. Light directed massively parallel on-chip synthesis of peptide arrays with t-Boc chemistry. Pro-teomics 2003 3 2135-2141. 

In 1991, scientists from the Affymax Research Institute combined photolithography, photochemistry, and solid-phase synthesis in a new technology called light-directed, spatially addressable parallel synthesis this technology has been reviewed. The principal points of this technology are illustrated in Scheme 1. 

Fodor SPA, Read J L, Pirrung M C, Stryer L, Lu A T and Solas D Light-directed, spatially addressable parallel chemical synthesis Science 252 767-73 Carter F L 1984 The molecular device computer point of departure for large scale cellular automata Physica D 10 175-94... 

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