Synthesis in action

In the last chapter, you saw examples of groups of sequential reactions used together to construct more complex organic molecules. We call these sequences syntheses, and our aim in this chapter is to show 

Making molecules, the job of the synthetic chemist, developed from a rather random process in the 

In this chapter we will look in detail at a few syntheses of important molecules. We hope you will appreciate that the chemistry you encountered in the first 24 chapters is being used all the time in chemical and pharmaceutical labs, in hospitals, and in industrial plants across the world to make valuable, sometimes life-saving, compounds. We start with two simple compounds made from one starting material toluene. 

Making molecules, the job of the synthetic chemist, developed from a rather random process in the nineteenth century into a well-ordered and well-understood science during the course of the twentieth century. Syntheses can even be planned (and, in some specialized cases, executed) by computers. But why do it  

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This Part of the book could as well have been titled "Synthesis in Action" for it consists of specific multistep sequences of reactions which have been demonstrated by experiment to allow the synthesis of a variety of interesting target molecules. Graphical flowcharts for each synthesis define precisely the pathway of molecular construction in terms of individual reactions and reagents. Each synthetic sequence is accompanied by references to the original literature. 

Drawing mechanisms chS Enthalpy and entropy Synthesis In action ch25... 

Carbonyl addition and substitution Regio-, stereo-, and chemoselectivity Synthesis in action ch25... 

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