Synthesis histone deacetylase

Bouchain G, Delorme D. (2003) Novel hydrozmate and anihde derivatives as potent histone deacetylase inhibitors Synthesis and antiproliferative evaluation. CurrMed Chem 10 2359-2372. 

Ting Y, Taori K, Kim H, Hong, Luesch H. (2008) Total synthesis and molecular target of largazole, a histone deacetylase inhibitor. J Am Chem Soc 130 8455-8459. 

Taunton J, Collins JL, Schreiber SL. (1996) Synthesis of natural and modified trapoxins, useful reagents for exploring histone deacetylase function. JAm Chem Soc 118 10412-10422. 

Yurek-George A, Habens F, BrimmeU M, Packham G Ganesan A. (2004) Total synthesis of spirnchostatin A, a potent histone deacetylase inhibitor. 

Design and synthesis of a potent histone deacetylase inhibitor. Journal of Medicinal Chemistry, 50, 2003-2006. 

Chen, P.C., Patil, V., Guerrant, W Green, P. and Oyelere, A.K. (2008) Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked... 

Lavoie, R., Bouchain, G., Frechette, S., Woo, S.H., Khalil, E.A., Leit, S.et al. (2001) Design and synthesis of a novel class of histone deacetylase inhihitors. Bioorganic ej Medicinal Chemistry Letters, 11, 2847-2850. 

Remiszewski, S.W., Samhucetti, L.C., Atadja, P., Bair, KW., Cornell, W.D., Green, M.A. et al. (2002) Inhihitors of human histone deacetylase Synthesis and enzyme and cellular activity of straight chain hydroxamates. Journal of Medicinal Chemistry, 45, 753—757. 

Andrianov, V., Gaihte, V., Lola, D., Loza, E., Semenikhina, V., Kalvinsh, L, Finn, P., Petersen, K.D., Ritchie, J.W., Khan, N., Tumber, A., Collins, L.S., Vadlamudi, S.M., Bjorkhng, F. and Sehested, M. (2008) Novel amide derivatives as inhibitors of histone deacetylase Design, synthesis and SAR. European Journal of Medicinal Chemistry.. ... 

Mai, A., Massa, S., Pezzi, R., Simeoni, S., Rotili, D., Nebbioso, A. etal. (2005) Class 11 (lla)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl) pyrrolyl hydroxyamides. Journal of Medicinal Chemistry, 48, 3344-3353. 

Suzuki, T., Ando, T., Tsuchiya, K., Fukazawa, N., Saito, A., Mariko, Y. et al. (1999) Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives. Journal of Medicinal Chemistry, 42, 3001-3003. 

Andrews, D.M., Gibson, K.M., Graham, M.A., Matusiak, Z.S., Roberts, C.A., Stokes, F.S.F. et al. (2008) Design and campaign synthesis of pyridine-based histone deacetylase inhibitors. Bioorganic ej Medicinal Chemistry Letters, 18, 2525-2529. 

Suzuki, T., Nagano, Y, Kouketsu, A., Matsuura, A., Maruyama, S., Kurotaki, M. et al. (2005) Novel Inhibitors of human histone deacetylases design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. Journal of Medicinal Chemistry, 48, 1019—1032. 

Sternson SM, Wong JC, Grozinger CM, Schreiber SL, Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin, Org. Lett., 3 4239-4242, 2001. 

Brown s crotylboration protocol was used effectively in the synthesis of azu-mamide A 28. Azumamides are unusual cyclic peptides that show potent inhibitory activity on histone deacetylase enzymes. A highly diastereo- and enan-tioselective (dr >99% 98% ee) crotylation of 3-benzyloxypropanal with the chiral reagent ( >crotyl-1Ipc2borane (l19E) afforded the homoallylic alcohol 29. Subsequent reductive ozonolysis and K2CO3-mediated hydrolysis of the acetate furnished the diol 3016 (Scheme 3.1m). 

Taunton, J., Collins, J. L., Schreiber, S. L. Synthesis of Natural and Modified Trapoxins, Useful Reagents for Exploring Histone Deacetylase Function. J. Am. Chem. Soc. 1996,118,10412-10422. 

Suzuki T et al (1999) Synthesis and histone deacetylase inhibitory activity of new benzamide derivatives. J Med Chem 42(15) 3001-3003... 

Montero A et al (2009) Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures. J Am Chem Soc 131(8) 3033—3041... 

Itoh Y et al (2007) Design, synthesis, structure-selectivity relationship, and effect on human cancer cells of a novel series of histone deacetylase 6-selective inhibitors. J Med Chem 50(22) 5425-5438... 

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