Synthesis Gallagher

In another synthesis, Gallagher described a fruitful approach based on the use of a carbohydrate enolate, which takes advantage of the presence of the C7 keto group in the target compound [265-267]. In this approach, an enolate had to be formed at the anomeric position of the gluco chiron, stable toward (3-elimination. Moreover, the use of a strained system, as in 357, should force enolization to occur on the correct side. 

Thomson JE, Kyle AF, Concellon C, Gallagher KA, Lenden P, Morrill LC, Miller AJ, Joannesse C, Slawin AMZ, Smith AD (2008) Synthesis 2805-2818... 

Copper deficiency in humans and other mammals is characterized by slow growth, hair loss, anemia, weight loss, emaciation, edema, altered ratios of dietary copper to molybdenum and other metals, impaired immune response, decreased cytochrome oxidase activity, central nervous system histopathology, decreased phospholipid synthesis, fetal absorption, and eventually death (NAS 1977 Gallagher 1979 Kirchgessner et al. 1979 USEPA 1980 ATSDR 1990 Percival 1995). 

In 1985, Lathbury and Gallagher reported the in situ synthesis of nitrones 191 from oximes 190 the 1,3-dipoles then could be trapped by a number of different alkenes 192 and thus the bicylic 193 was obtained (Scheme 15.61) [122],... 

Gallagher has reported a convenient synthesis of functionalized phosphorinans (102) by Michael addition of methyl hypophosphite to methyl acrylate, followed by base-induced cyclization.78... 

J.-M. Beau T. Gallagher NudeophilicC-Glycosyl Donors for C-[Pg.54]

Beau J-M and Gallagher T (1997) Nucleophilic C-Glycosyl Donors for C-Glycoside Synthesis. 187 1-54... 

In a series of reports, Gallagher and co-workers (51,52) outlined the use of azomethine ylide technology in the construction of the bicyclic core of p-lactams. Initially the synthesis of carbapenems was studied. The oxazolidine-based ylide precursor 185 was prepared by a literature precedent and submitted to thermolytic... 

In their synthesis of the anti-leukaemia compound steganone, Magnus, Schultz and Gallagher used the allylic alcohol 65 to make the cyclopropane 66. The extra carbon atom was incorporated into the eight-membered ring of steganone.16... 

Jones oxidation conditions were identical to those used in a synthesis of (-)-a-kainic acid 2 with the reaction time extended to 18 h Cooper, J. Knight, D. W. Gallagher, P. T. J. Chem. Soc. Perkin Trans. 11992,553. 

---