Syntenic regions

An important question concerns the effect of the minor shift on the isochore pattern. This problem has been explored on all syntenic regions shared by human and mouse, that were large enough to comprise more than one isochore. The results of this investigation (Pavli-cek et al., 2002b) indicate that the human isochore pattern is still recognizable in the mouse chromosomes after the minor shift. This will be illustrated here by considering the major histocompatibility (MHC) locus. 

Ferguson GD, Chen XN, Korenberg JR, Herschman HR. 2000b. The human synaptotagmin IV gene defines an evolutionary break point between syntenic mouse and human chromosome regions but retains ligand inducibility and tissue specificity. J Biol Chem 275(47) 36920-36926. 

Stanier, R, Henson, J. N., Eddleston, J., Moore, G., and Copp, A. J. (1995). Genetic basis of neural tube defects The mouse gene loop-tail maps to a region of chromosome 1 syntenic with human Iq21-q23. Genomics 26,473—478. 

Hume I think they had to have at least 10 genes. This is conserved between mouse and human in that those regions are syntenic in human. 

Lichto OP, Walczak H, Weitz S, Behnnann I, Krammer PH. The human APO-1 (APT) antigen maps to 10q21, a region that is syntenic with mouse chromosome 19. Genomics 992 14 179-180. 

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