Syndrome type peripheral neuropathy

Some patients may experience hearing loss, which may accompany diabetes. Usually, type 2 diabetes is described in individuals with MELAS, although type 1 or insulin-dependent diabetes also may be observed. Palpitations and shortness of breath may be present in some patients with MELAS secondary to cardiac conduction abnormalities such as Wolff-Parkinson-White syndrome. Acute onset of gastrointestinal manifestations (e.g., acute onset of abdominal pain) may reflect pancreatitis, ischemic colitis, and intestinal obstruction. Numbness, tingling sensation, and pain in the extremities can be manifestations of peripheral neuropathy. Some patients may have the presentation of Leigh syndrome (i.e., subacute necrotizing encephalopathy). 

The development of type 2 diabetes coincides with progressive obesity but occurs in individuals who are genetically susceptible. The risks of diabetes include microvascular disease, resulting in diabetic retinopathy and nephropathy, along with a number of different forms of neuropathy, and accelerated systemic atherosclerosis, resulting in coronary artery, cerebrovascular, and peripheral vascular disease. The atherosclerosis of diabetes is complex, but is not entirely dependent on hyperglycemia since patients with insulin resistance, hyperinsulinemia, and the metabolic syndrome are also at increased risk for atherosclerosis. There is a strong statistical association between obesity and metabolic syndrome, and most patients will demonstrate some feamres of metabolic syndrome with more severe obesity. A minority... 

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