Synaptic GABAa-R Gene Expression During Pregnancy and after Delivery

Changes in Synaptic GABAa-R Gene Expression During Pregnancy and After Delivery 

These results provide further support to the notion that both the structure and function of GABAa-Rs in the brain change during pregnancy and immediately after delivery as a result of the marked associated fluctuations in the brain levels of neuroactive steroids. 

GABAA-R-mediated sIPSCs were examined and we found that the marked increase of decay time constant, amplitude, and area caused by this neurosteroid was not different between rats at PI9 and those in estrus. Similarly, the potentiation of sIPSCs recorded in dentate gyrus granule cells induced by the benzodiazepine lorazepam (3 /lM), although slightly reduced in rats at PI9 compared to control, resulted not different among these animals. 

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