Targeting Symptoms

Contains the health hazards and risks, toxicological data, and first aid procedures Exposure routes and limits signs and symptoms target organs and medical conditions aggravated by exposure. 

Starting dose usually the same as the maintenance dose Onset of response usually 3 to 8 weeks Response is frequently complete remission of symptoms Target symptoms do not worsen when treatment initiated... 

Symptom-targeted therapy includes decreasing pulmonary venous pressure, maintaining atrial contraction and atrioventricular (AV) synchrony, and reducing heart rate. Exercise tolerance is increased by reducing exercise-induced increases in blood pressure and heart rate. 

An important step in symptom-targeted therapy that acts to decrease pulmonary venous pressures is to maintain atrial contraction and atrioventricular (AV) synchrony. Maintaining atrial contraction and AV synchrony is important both in preserving normal cardiac output and in keeping LV diastolic pressure low. Chemical or electrical cardioversion of persistent atrial tachyarrhythmias will decrease diastolic pressure, increase cardiac output, and resolve pulmonary edema. An AV sequential pacemaker should be used to treat bradyarrhythmias in patients requiring pacing. 

Diuretics can provide symptom-targeted therapy by acting to... 

Similar to diuretics, nitrates can provide symptom-targeted therapy by acting to decrease LV volume by increasing venous capacitance. In addition, nitrates can provide disease-targeted therapy by providing anti-ischemic effects in patients with DHF owing to CAD. 

Exposure Routes, Symptoms, Target Organs (see Table 5) ER Inh, Ing, Con SY Irrit eyes, skin, resp sys TO Eyes, skin, resp sys First Aid (see Table 6) Eye Irr immed Skin Blot/brush away Breath Fresh air Swallow Medical attention immed ... 

Exposure Routes, Symptoms, Target Organs (see Table 5) First Aid (see Table 6) ... 

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