Symbiotic marine microorganism

Kobayashi, J. and Ishibashi, M., Bioactive metabolites of symbiotic marine microorganisms, Chem. Rev., 93, 1753, 1993. 

N- and O-Heterocycles bioactive metabolites of symbiotic marine microorganisms 93CRV1753. 

The structure of piimaic acid (24) from the bivalve P. muricata has been shown to be closely similar to that of halichlorine (26) from the marine sponge H. okadai. Each carbon atom has been tentatively numbered according to the supposed biogenetic formation of the N-C23 bond. Thus, these two bioactive metabolites may each be biosynthesized by symbiotic marine microorganisms. 

Finally, recent reviews indicate that marine microorganisms are potentially a greater source of bioactive compounds than marine macroorganisms,78 81 Marine microorganisms can be found in seawater or sediment, associated with macroorganisms either on the surface or symbiotically, and in extreme environments. Extremophiles, in particular, may have the greatest capacity for the production of unique bioactive metabolites.78... 

Metabolites of Free-Living, Commensal, and Symbiotic Benthic Marine Microorganisms... 

Thousands of bioactive compounds that have fascinating potentials to develop as nutraceuticals have been identified from marine sources. This chapter investigates the possibility of developing nutraceuticals from bioactive compounds, identified from marine sponges and symbiotic microorganisms. 

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