Sweetening agents mannitol

Both solid and liquid dosage forms may contain saccharin. Saccharin is a nonnutritive sweetening agent, which is 300 times as sweet as sucrose. In a survey of sweetener content of pediatric medications, seven out of nine chewable tablets contained saccharin (0.45-8.0 mg/tablet) and sucrose or mannitol. Seventy-four of the 150 liquid preparations investigated contained saccharin (1.25-33 mg/5 mL) [62], Saccharin is a sulfanamide derivative that should be avoided in children with sulfa allergies [54],... 

In addition to sucrose, a number of other sweetening agents have been utilized in foods and pharmaceuficals over the years, including dextrose, mannitol, sorbitol, aspartame, saccharin, and others. Some sweeteners, such as sucrose, aid in preserving the product. 

Sorbitol is a hexahydric alcohol that is isomeric with mannitol, and which has been described as a humectant, plasticizer, sweetening agent, and tablet and capsule diluent. It is used extensively in the pharmaceutical, cosmetics, and food industries, since it has a sweet taste and approximately 50-60% the sweetness of sucrose. 

In 1883 Jaffe showed that D-mannitol could be fed to dogs and recovered unchanged in large quantities from the urine. In rabbits the compound was partially metabolized. Sollmann suggests the use of mannitol as a sweetening agent in the diabetic diet. In 1919 Field d... 

An acceptable daily intake of mannitol has not been specified by the WHO since the amount consumed as a sweetening agent was not considered to represent a hazard to health. ... 

D-mannitol is widely used as sweetening agent and finds also different application in the food industry and related areas [1]. D-mannitol can be directly prepared from mannose or by stereoselective hydrogenation of D-fructose. However, the hydrogenation of D-fructose in aqueous solution over different heterogeneous catalysts leads to the formation of two isomers, i.e. D-mannitol and D-sorbitol, near to a ratio of one to one [1]. 

Other alditols common in the biological world are erythritol, D-mannitol, and xylitol. Xylitol is used as a sweetening agent in "sugarless" gum, candy, and sweet cereals. 

The use of foods containing artificial sweetening agents such as saccharin and aspartame, and the use of polyols like mannitol, soibitol, and xylitol, may decrease the incidence of caries, since bacteria of the mouth cannot ferment these sweeteners to acids. 

USE Used with boric acid in the manuf of dry electrolytic condensers for radio applications in making artificial resins and plasticizers in pharmacy as excipient and diluent for solids and liqs in analytical chemistry for boron determinations in the manuf of mannitol hexanitrate. Used in the food industry as anticaking and free f]ow agent flavoring agent, Lubricant and release agent, stabilizer and thickener and nutritive sweetener,... 

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