Surgery, proteases used

Aprotinin. Aprotinin is a naturally occurring serine protease inhibitor, has found widespread applications either by the intravenous route or as a component of biological sealants, because of its ability to decrease blood loss, and, as a consequence, transfusion requirements. Anaphylactic reactions are mediated by IgG and IgE antibodies. The risk of anaphylactic reactions has been estimated between 0.5 and 5.8% when used intravenously during cardiac surgery, and at 5 for 100,000 applications when used as a biologic sealant [25]. Patients previously treated with this drug present an increased risk and any new administration should be avoided for at least 6 months following an initial exposure [25]. 

Indications For prophylactic use to reduce blood loss in patients undergoing coronary artery bypass surgery Category Antifibrinolytic Protease inhibitor Half-life 150 minutes... 

M05A B Antiinflammatory enzymes A variety of animal and plant proteases are used to reduce inflammation and swellings in wounds and abscesses after minor dental surgery, for example. The plant enzymes include papain, bromelains and ficin. These and animal enzymes such as trypsin and chy-motrypsin (pancreatic enzymes) are used as debriding agents in burn tissue, pus etc. 

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