Surface plasmon sensitivity

Surface plasmon resonance has become an important optical technique employed in chemical sensing and biotechnological measurements/ As a surface phenomenon, surface plasmons sensitively reflect upon the boundary conditions at the interface of a plasma-like medium. In this regard, they react to the introduction of adsorbate material... 

Nano-Enhancement of Surface Plasmon Sensitivity (LSPR Technique). 89... 

There are a few other surface-sensitive characterization techniques that also rely on the use of lasers. For instance surface-plasmon resonance (SPR) measurements have been used to follow changes in surface optical properties as a fiinction of time as the sample is modified by, for instance, adsorption processes [ ]. SPR has proven usefiil to image adsorption patterns on surfaces as well [59]. 

Lukosz W., Principles and sensitivities of integrated optical and surface plasmon sensors for direct affinity sensing and immunosensing, Biosens. Bioelectron. 1992 6 261-289. 

M. Zayats, O.A. Raitman, V.I. Chegel, A.B. Kharitonov, and I. Willner, Probing antigen-antibody binding processes by impedance measurements on ion-sensitive field-effect transistor devices and complementary surface plasmon resonance analyses development of cholera toxin sensors. Anal. Chem. 74, 4763-4773 (2002). 

Long period gratings modified by the deposition of a self-assembled colloid monolayer of gold have been shown to enhance SRI sensitivity, which was attributed to the localized surface plasmon resonance (LSPR) of gold nanoparticles61. The system was used after functionalization of the gold nanoparticles with dini-trophenyl (DNP) antigen, for the detection of anti-(DNP) with a limit of detection as low as 9.5 x 10 10 M. 

Hoa, X. D. Kirk, A. G. Tabrizian, M., Towards sensitive and integrated surface plasmon resonance biosensors A review of recent progress, Biosens. Bioelectron. 2007, 23, 151 160... 

However, the determination of affinity does not necessarily have to rely on labeled ligands. It is also possible with native ligands when using suitable detection methods, as for example nuclear magnetic resonance (NMR), surface plasmon resonance (SPR), acoustic biosensors or calorimetry [48, 49]. A particularly versatile and sensitive detection principle for the investigation of interactions between targets and native ligands is mass spectrometry [50]. 

---