Supported Reagent Chemistry

Some of the key advantages of supported reagents compared to the unsupported reagent are  

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Jamieson C, Congreave MS, Emiabata-Smith DF, Ley SV, Scicinski J (2002) application of ReactArray robotics and design of experiments techniques in optimisation of supported reagent chemistry. J Org Proc Res Dev 6 823-825... 

The benefits brought by the supported reagent chemistry are considerable efficiency, low cost, possibility of reusing the supports, implementation of nontoxic and cheap materials, ease of set-up and work-up, minimization of pollution, possibility to work in solvent-free conditions. 

International Symposium Supported Reagent Chemistry, Royal Society of Chemistry, University of York, 2-5 July, 1991. 

P. Pfeifer, in Preparative Chemistry Using Supported Reagents, P. Laszlo, ed.. Academic, New York, 1987. 

It years, there has been a considerable growth of interest in the catalysis of organic IS by inorganic reagents supported on high surface areas, Envirocat, a new family of supported reagents, which exhibits both Bronstead and Lev/is acid character, are ideal for environmentally friendly chemistry. These reagents are non-toxic powders that can be easily... 

Viewed in conjunction with the solid-like, nonvolatile nature of ionic liquids, it is apparent that TSILs can be thought of as liquid versions of solid-supported reagents. Unlike solid-supported reagents, however, TSILs possess the added advantages of kinetic mobility of the grafted functionality and an enormous operational surface area (Figure 2.3-1). It is this combination of features that makes TSILs an aspect of ionic liquids chemistry that is poised for explosive growth. 

J. H. Clark and C.N. Rhodes, Clean Synthesis Using Porous Inorganic Solid Catalysts and Supported Reagents , Royal Society of Chemistry, Cambridge, 2000. 

Many examples of such benzylic instability are provided by classical (free-molecule) organic chemistry, as well as a few by the smaller and more specialized field of polymer-supported reagents and catalysts. Hence ... 

Silica-supported reagents have been exploited as nontoxic, inexpensive, reusable, and environmentally acceptable catalysts for developing stoichiometric reaction methods in organic chemistry and specifically in carbohydrate chemistry. Apart from being easy to handle and to store, these systems allow facile workup, the catalyst being removed by simple filtration, and the reaction products isolated by chromatographic purification, if necessary. 

Heterocyclic chemistry has benefited substantially from MW-expedited processes developed over the last decade. An exhaustive overview is provided in adjoining chapters [87, 88] with limited solvent-free chemistry utilizing mineral supported reagents being covered in this section. 

The use of polymer-supported reagents in combinatorial chemistry has received much attention in recent years, and a polymer-supported acylating reagent (supported on a ROMPGEL) has been used for the synthesis of 1,2,4-oxadiazoles in solution, (see Equation 37), <2000CCHT131>. 

S. W. Kaldor, M. G. Siegel, Combinatorial Chemistry using Polymer supported Reagents , Cun. Opin. Chem Bio. 1997,1,101. 

The clean and efficient production of azo dyes is a classical chemistry problem. The manufacture of this industrially important family of compounds is traditionally associated with the additional formation of large quantities of hazardous and colored waste. A method for the construction of both phenolic and amino azodyes has been reported using a polymer-supported nitrite reagent to effect diazoti-zation of aromatic amines (Scheme 2.53) [80]. Waste minimization and operational simplicity, along with improved separation technologies, are key advantages of polymer-supported reagents in this area. 

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