Supersensitization system

QUESTION If anything was preventing a reward system from being operative, you would, perhaps, tend to see this inhibitory effeet behaviorally. With supersensitization, do you have this kind of a eonsequenee to beat the reward system not being activated ... 

Photoconductivity in photographic systems. II. Some applications to the phenomena of supersensitization, desensitization and the Becquerel effect. J. chem. Physics 15, 539 (1947)-... 

On balance, these actions could support a decrease rather than an increase in the functional state of CNS NE transmission, because depression can be conceptualized as a state of supersensitive catecholamine receptors secondary to decreased NE availability. This reasoning is consistent with the original hypothesis of diminished NE functioning, with antidepressants returning receptors to a more normal state of sensitivity. Siever and Davis ( 41) further elaborated on this concept by suggesting the possibility of dysregulation in the homeostatic mechanisms of one or more neurotransmitter systems, culminating in an unstable or erratic output. 

Reducing agents, such as hydroquinone, Br , I, SCN- ions, and others, are used as supersensitizers for electron photoinjection reactions. Figure 28 illustrates how an admixture of hydroquinone affects photocurrent in the system CdS—rhodamine B. In certain cases the solvent, water, can also act as a supersensitizer. For example, if the bipyridyl complex of Ru(II) is a sensitizer, the oxidized form, the complex of Ru(III), can oxidize water to oxygen... 

The use of novel electrode materials should, in principle, improve the reproducibility of the biosensor, since the screen-printing process is thought to be responsible for the standard deviation of the electrochemical measurements. The developed biosensor can also be applied to the analysis of water. In this case, the matrix is expected to produce fewer effects. Finally, the use of molecularly engineered supersensitive enzymes and the combination with signal amplification systems can contribute to increase the sensitivity of the biosensor. 

Fann et al., 1980 Klawans, 1973 and chapter 5 in this volume). This supersensitivity of the dopamine receptors becomes most obvious when the drug is reduced or eliminated, terminating the blockade. The over-active, unblocked receptors produce the TD symptoms. Undoubtedly, a great deal more must be learned about the neuropathology of both these drug-induced diseases, which probably involve multiple neurotransmitter system abnormalities. However, if health care providers were to stop prescribing these drugs to patients, the problem would virtually disappear. 

One of the panelists, Barry D. Jones, warned, Some patients who seem to require lifelong neuroleptics may actually do so because of this therapy. In the published version (Chouinard et al., 1980), the authors suggested that the irreversible supersensitivity psychosis results from rebound hyperactivity of the blockaded dopamine receptors in the limbic system. They compared the mechanism of supersensitivity psychosis to that of TD. Tardive psychosis may be a mental manifestation of the same processes that cause the motor phenomena of TD. 

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