Superoxide scavenging activity

Tsuji, A., Oka, S., Sano, Y., Matsushita, R., Takada, J., Sakurai, H., Superoxide scavenging activity and metal contents of coffee, Biomed. Res. Trace Elem., 6(2), 101, 1995. (CA124 230604h)... 

We have used the nitration of a tyrosine analog with superoxide dismutase to measure the peroxynitrite production from activated rat alveolar macrophages (Fig. 38). The estimated rate of peroxynitrite synthesis was estimated to be 0.1 nmol/10 cells/min (Ischiropoulos et al., 1992a). The rate of nitration was the same whether native Cu,Zn-superoxide dismutase or the phenylglyoxyl-H202 modified superoxide dismutase (which is >99% inhibited with respect to its superoxide scavenging activity) was used (Fig. 39). Three other independent but indirect estimates of peroxynitrite formation were consistent with the superoxide... 

J. P. Hu and co-workers, Structure-Activity Relationship ofFlavonoids with Superoxide Scavenging Activity, Biological Trace Element Research, Vol. 47, The Humana Press Inc., Clifton, N.J., pp. 327—331,1995. 

Minami, H., Takahashi, E., Fukuyama, Y., Kodama, M., Yoshizawa, T. and Nakagawa, K. (1995) Novel xanthones with superoxide scavenging activity from Carcinia subelliptica. Chemical and Pharmaceutical... 

N.V.Gulyaeva. Superoxide scavenging activity of carnosine in the presence of copper and zinc ions. Biochemistry- Moscow. 52 (1987) 1216-1220. 

Mulberroside F (104) showed moderate inhibitory effects on tyrosinase activity and on the melanin formation of melan-a cells. It also exhibited superoxide scavenging activity that is involved in the protection against auto-oxidation [62]. The geranylated stilbenes 81 and chlorophorin from Chlorophora excelsa [51], prenylated ones 4-prenyloxyresveratrol and artocarbene (72) from Artocarpus incisus [528] all demonstrated tyrosinase inhibitory activity (ICso 96, 1.3, 0.66 and 2.45 //M, respectively). 

Cu(TpMe)2] prepared from the reaction of CuCl2 with K(TpMe) has been characterized by magnetic susceptibilities, fast atom bombardment and IR spectrometry, and X-ray single-crystal study.1 Cop-per(I) complexes containing water soluble phosphines, [Cu(TpMe)(L)] (L = 4- or 2-(diphenylphosphane)benzoic acid), have been characterized by IR in the solid state, and by NMR (JH and 31P 1H ) and electrospray mass spectroscopy in solution. Chemiluminescence technique was used to evaluate their superoxide scavenging activity.2... 

A chemiluminescence study has demonstrated the superoxide scavenging activity of some [Cu(Tpx)(PR3)] complexes.241,242 Selected complexes were investigated as antioxidants in mitigating oxidative DNA damage. 

Compounds 25, 26 and 27 belonging to I-C group, isolated from Vatica rassak and V. indica, showed antioxidation and SOD like activities, indicating that this group of oligomers also has antioxidation activity and superoxide scavenging activity [58,59, 60]. 

Haraguchi H, Ishikawa H, Mizutani K, Tamura Y, Kinoshita T (1998) Antioxidative and superoxide scavenging activities of retrochalcones in Glycyrrhiza inflata. Bioorg Med Chem 6 339... 

IC50 The concentration of tested compound (pM) for exhibiting 50% superoxide scavenging activity. 

Bazin MA, Le Lamer AC, Delcros JG et al (2008) Synthesis and cytotoxic activities of usnic acid derivatives. Bioorg Med Chem Lett 16 6860-6866 BeGora MD, Fahselt D (2001) Usnic acid and Atranorin concentrations in lichens in relation to bands of UV irradiance. Bryologist 104 134-140 Behera BC, Adawadkar B, Makhija U (2003) Inhibitory activity of xanthine oxidase and superoxide-scavenging activity in some taxa of the lichen family Graphidaceae. Phytomedicine 10 536-543... 

Behera BC, Adawadkar B, Makhija U (2003) Inhibitory activity of xanthine oxidase and superoxide-scavenging activity in some taxa of the lichen family Graphidaceae. Phytomedicine 10 536-543... 

Nakamura, Y, Ohto, Y, Murakami, A and Ohigashi, H (1998) Superoxide scavenging activity of rosmarinic acid from Perilla frutescens Britton var. acuta f. virdis. J. Agric. Food Chem., 46, 4545-1550. 

Beissenhirtz MK, Kwan RCH, Ko KM, Renneberg R, Scheller FW, Lisdat F (2004) Comparing an In vitro electrochemical measurement of superoxide scavenging activity with an in vivo assessment of antioxidant potential in Chinese tonifying heibs. Phyt Res 18 149-153... 

Chemiluminescent assay for superoxide-scavenging activity of aldehyde-modified HSA... 

Xanthine/xanthine oxidase (X/XO) system was used to generate O2 to measure the superoxide-scavenging activity of aldehyde-modified HSA. Briefly, 1 ml solution contained 100 pg/ml X, 0.01 U/ml XO, 250 pM DTPA and 500 pM luminol in the absence or presence of 10 nM of aldehyde-modifed HSA. Chemiluminescent intensity was recorded as described above. 

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