Sunfish metabolism

Benke GM, Cheever KL, Mirer FE, et al. 1974. Comparative toxicity, anticholinesterase action and metabolism of methyl parathion and parathion in sunfish and mice. Toxicol Appl Pharmacol 28 97-109. 

Cruz SM, MN Scott, AK Merritt (1993) Metabolism of fCjmetolachlor in blueguill sunfish. J Agric Food Chem 41 662-668. 

Along with degree of chlorination another determinant of PCB metabolism in fish is species. Green sunfish and goldfish rapidly metabolize 2,2, 5-trichlorobiphenyl whereas bullheads and rainbow trout metabolize it slowly (26,29). There is little evidence for PCB metabolism in brook trout fed 4-chloro-, 4,4 -dichloro-, 2,2, 5,5 -tetrachloro- or 2,2, 4,4, 5,5 -hexachloro-biphenyl (31) and this was confirmed in rainbow trout by less than 1% of 2,2, 5,5 -tetrachlorobiphenyl accumulated being recovered as polar metabolites (25). 

Elimination. Rate that PCBs are eliminated by fish is strongly influenced by their rate of metabolism. Figure 7 shows concentration of PCB in green sunfish after being exposed to a high or low dose of 2,2, 5-trichlorobiphenyl or 2,2, 4,5,5r-pentachlorobiphenyl on day 0 and again on day 9 (26). Of these... 

Jimenez, B.D. Cirmo, C.P. McCarthy, J. F. 1987, Effects of feeding and temperature on uptake, elimination and metabolism of benzo[a]pyrene in the bluegill sunfish ILepomis macrochims). Aquat. Toxicol. 10 41-57. 

Appleton, H.T. and Sikka, H.C. Accumulation, elimination, and metabolism of dichlorobenzidine in the bluegill sunfish,... 

The US Interagency Testing Committee estimated BCFs for N-EtFOSE and N-McFOSE using structure-activity models to be 5543 and 26000, respectively [77]. These values are likely in error because the rate of metabolism was not a consideration in this exercise. Although the data quality is suspect, the apparent bioconcentration factor for N-EtFOSE was approximately 400 in bluegill sunfish and channel catfish [78]. As far as we are aware, this is the only existing experimental bioaccumulation data for any PFA precursor. 

Gerking, S.D. (1952).The protein metabolism of sunfishes of different ages. Physiological Zoology 25,358-372. 

Appleton, H., Sikka, H. (1980) Accumulation, elimination and metabolism of dichlorobenzidine in bluegill sunfish. Environ. Sci. Technol. 14, 50-54. 

Reinbold, K.A. and R.L. Metcalf. Effects of the synergist piperonyl butoxide on metabolism of pesticides in green sunfish. Pestic. Biochem. Physiol. 6 401-412, 1976. 

Animals quickly metabolize and eliminate thiazopyr (Table 7.1). Rat-liver microorganisms use sulfur and carbon oxidation along with deesterification for degradation. Studies in blueghl sunfish demonstrated 98% elimination within 14 days. 

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