Summary of Morphine-Induced Hemodynamic and Cutaneous Changes in Humans

3 Summary of Morphine-Induced Hemodynamic and Cutaneous Changes in Humans 

Infusion studies designed to examine the relationship between human plasma histamine levels and symptoms revealed that from resting levels of 0.62 ng/ml, 1.61 ng/ml of histamine produced a 30 % increase in heart rate, 2.39 ng/ml elicited flush and headache, and 2.45 ng/ml was followed by a 30 % increase in pulse pressure. Venous blood plasma histamine levels were monitored after intradermal injection of morphine to induce cutaneous mast cell degranulation and the findings (Table 8.4) were compared with the results of 

Route of administration (or in vitro study) and dose (or concentration) of morphine used Histamine release Hemodynamic and other effects Reference 

15 mg/kg IV Symptoms of histamine release but no hemodynamic changes Doenicke et al. Chn Pharmacol Ther. 1995 58 81 

5xl0- Mtol.5xl0-3M intradermal skin tests f wheal and flare Levy et til. Anesthesiology. 1989 70 756 

---